The increasing life expectancy of humans has led to a growing numbers of patients with
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …

The shortage of organs and cells from deceased individuals continues to restrict
allotransplantation. Pigs could provide an alternative source of tissue and cells but the …

The shortage of available organs remains the greatest barrier to expanding access to
transplant. Despite advances in genetic editing and immunosuppression, survival in …

There is a critical shortage in the number of deceased human organs that become available
for the purposes of clinical transplantation. This problem might be resolved by the …

Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Xenotransplantation has the potential to alleviate the organ shortage that prevents many
patients with end‐stage renal disease from enjoying the benefits of kidney transplantation …

▪ Abstract The increasing shortage of human cadaveric organs for purposes of
transplantation has become the critical limiting factor in the number of transplants performed …

Xenotransplantation may be a solution to overcome the shortage of organs for the treatment
of patients with organ failure, but it may be associated with the transmission of porcine …

Xenotransplantation using pig organs has achieved survival times up to 195 days in pig
orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an …