Lung endothelium, tau, and amyloids in health and disease
Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …
The battle within: how Pseudomonas aeruginosa uses host-pathogen interactions to infect the human lung
C Mesas Vaz, A Guembe Mülberger… - Critical Reviews in …, 2024 - Taylor & Francis
Pseudomonas aeruginosa is a versatile Gram-negative pathogen known for its ability to
invade the respiratory tract, particularly in cystic fibrosis patients. This review provides a …
invade the respiratory tract, particularly in cystic fibrosis patients. This review provides a …
Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens
Bacterial human pathogens secrete initially inactive nucleotidyl cyclases that become potent
enzymes by binding to actin inside eukaryotic host cells. The underlying molecular …
enzymes by binding to actin inside eukaryotic host cells. The underlying molecular …
Prevalence of ExoY Activity in Pseudomonas aeruginosa Reference Panel Strains and Impact on Cytotoxicity in Epithelial Cells
H Silistre, D Raoux-Barbot, F Mancinelli… - Frontiers in …, 2021 - frontiersin.org
ExoY is among the effectors that are injected by the type III secretion system (T3SS) of
Pseudomonas aeruginosa into host cells. Inside eukaryotic cells, ExoY interacts with F-actin …
Pseudomonas aeruginosa into host cells. Inside eukaryotic cells, ExoY interacts with F-actin …
Bacterial nucleotidyl Cyclases activated by calmodulin or actin in host cells: enzyme specificities and cytotoxicity mechanisms identified to date
M Teixeira-Nunes, P Retailleau, M Comisso… - International Journal of …, 2022 - mdpi.com
Many pathogens manipulate host cell cAMP signaling pathways to promote their survival
and proliferation. Bacterial Exoenzyme Y (ExoY) toxins belong to a family of invasive …
and proliferation. Bacterial Exoenzyme Y (ExoY) toxins belong to a family of invasive …
Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin
M Teixeira Nunes, P Retailleau, D Raoux-Barbot… - PLoS …, 2023 - journals.plos.org
ExoY virulence factors are members of a family of bacterial nucleotidyl cyclases (NCs) that
are activated by specific eukaryotic cofactors and overproduce cyclic purine and pyrimidine …
are activated by specific eukaryotic cofactors and overproduce cyclic purine and pyrimidine …
A Robust and Sensitive Spectrophotometric Assay for the Enzymatic Activity of Bacterial Adenylate Cyclase Toxins
Various bacterial pathogens are producing toxins that target the cyclic Nucleotide
Monophosphate (cNMPs) signaling pathways in order to facilitate host colonization. Among …
Monophosphate (cNMPs) signaling pathways in order to facilitate host colonization. Among …
[PDF][PDF] A Robust and Sensitive Spectrophotometric Assay for the Enzymatic Activity of Bacterial Adenylate Cyclase Toxins. Toxins 2022, 14, 691
Various bacterial pathogens are producing toxins that target the cyclic Nucleotide
Monophosphate (cNMPs) signaling pathways in order to facilitate host colonization. Among …
Monophosphate (cNMPs) signaling pathways in order to facilitate host colonization. Among …