Osteosarcoma, a predominant malignant bone tumor, poses significant challenges due to its
high metastatic and recurrent nature. Although various therapeutic strategies are currently in …

Introduction: Osteosarcoma is the most common malignant bone tumor. It is currently treated
with pre-and postoperative chemotherapy, associated with surgical resection of the tumor …

Osteosarcoma is the most common primary malignant bone tumor, occurring mainly in
children and adolescents, and the limbs are the main affected sites. At present, limb‐salvage …

Background Use of an implant is one of the risk factors for surgical site infection (SSI) after
malignant bone tumor resection. We developed a new technique of coating titanium implant …

Bone sarcomas account for approximately 0.2% of new cancer cases in the United States
each year. The vast majority of these are either osteosarcoma, Ewing sarcoma, or …

Background: Few studies have analyzed the benefit of limb amputations in children with
metastatic osteosarcoma and limited life span. Objective: We studied outcomes of limb …

Background Surgical resection with negative margins is the foundation of extremity sarcoma
management. Failure to achieve negative surgical margins can result in local recurrence …

Bioceramics such as calcium silicate (Ca-Si), have gained a lot of interest in the biomedical
field due to their strength, osteogenesis capability, mechanical stability, and biocompatibility …

Background Osteosarcoma is the most common pediatric malignant bone tumor, frequently
surgically managed with limb salvage rather than amputation. Local recurrences are seen in …

Background AZD7762 is a checkpoint kinase 1 (Chk 1) inhibitor, which has been reported to
sensitize many tumor cells to DNA damage. However, whether AZD7762 could sensitize …