Abstract Purpose Amorphous solid dispersions (ASDs) have been widely used in the
pharmaceutical industry for solubility enhancementof poorly water-soluble drugs. The …

Many pharmaceutical drugs in the marketplace and discovery pipeline suffer from poor
aqueous solubility, thereby limiting their effectiveness for oral delivery. The use of an …

Drug loading is an important parameter known to impact the release rate of a poorly soluble
drug from an amorphous solid dispersion (ASD). Recent studies have shown that small …

As a promising strategy, amorphous solid dispersion has been extensively employed in
improving the oral bioavailability of insoluble drugs. Despite the numerous advantages, the …

It is well known that small molecule colloidal aggregation is a leading cause of false
positives in early drug discovery. Colloid-formers are diverse and well represented among …

Does the performance of an amorphous solid dispersion rely on having 100% amorphous
content? What specifications are appropriate for crystalline content within an amorphous …

Spray drying is widely used in the manufacturing of amorphous solid dispersion (ASD)
systems due to its fast drying rate, enabling kinetic trapping of the drug in amorphous form …

Compared to their crystalline forms, amorphous pharmaceutical solids present marvelous
potential and advantages for effectively improving the oral bioavailability of poorly water …

Amorphous solid dispersions (ASDs) are used to increase the solubility of oral medicines by
kinetically stabilizing the more soluble amorphous phase of an active pharmaceutical …

Among many methods to mitigate the solubility limitations of drug compounds, amorphous
solid dispersion (ASD) is considered to be one of the most promising strategies to enhance …