Behind the scenes: How RNA orchestrates the epigenetic regulation of gene expression
Non-coding DNA accounts for approximately 98.5% of the human genome. Once labeled as
“junk DNA”, this portion of the genome has undergone a progressive re-evaluation and it is …
“junk DNA”, this portion of the genome has undergone a progressive re-evaluation and it is …
LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes
Constitutive heterochromatin is responsible for genome repression of DNA enriched in
repetitive sequences, telomeres, and centromeres. During physiological and pathological …
repetitive sequences, telomeres, and centromeres. During physiological and pathological …
Key concepts in muscle regeneration: Muscle “cellular ecology” integrates a gestalt of cellular cross-talk, motility, and activity to remodel structure and restore function
JE Anderson - European journal of applied physiology, 2022 - Springer
This review identifies some key concepts of muscle regeneration, viewed from perspectives
of classical and modern research. Early insights noted the pattern and sequence of …
of classical and modern research. Early insights noted the pattern and sequence of …
Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment
E Martinez-Terroba, LM Plasek-Hegde… - Science …, 2024 - science.org
Expression of the long noncoding RNA (lncRNA) metastasis–associated lung
adenocarcinoma transcript 1 (MALAT1) correlates with tumor progression and metastasis in …
adenocarcinoma transcript 1 (MALAT1) correlates with tumor progression and metastasis in …
Selective concurrence of the long non-coding RNA MALAT1 and the polycomb repressive complex 2 to promoter regions of active genes in MCF7 breast cancer cells
F Arratia, C Fierro, A Blanco, S Fuentes… - Current Issues in …, 2023 - mdpi.com
In cancer cells, the long non-coding RNA (lncRNA) MALAT1 has arisen as a key partner for
the Polycomb Repressive Complex 2 (PRC2), an epigenetic modifier. However, it is …
the Polycomb Repressive Complex 2 (PRC2), an epigenetic modifier. However, it is …
RADIP technology comprehensively identifies H3K27me3-associated RNA–chromatin interactions
X Shu, M Kato, S Takizawa, Y Suzuki… - Nucleic Acids …, 2024 - academic.oup.com
Many RNAs associate with chromatin, either directly or indirectly. Several technologies for
mapping regions where RNAs interact across the genome have been developed to …
mapping regions where RNAs interact across the genome have been developed to …
H19 inhibition increases HDAC6 and regulates IRS1 levels and insulin signaling in the skeletal muscle during diabetes
A Kumar, M Datta - Molecular Medicine, 2022 - Springer
Abstract Background Histone deacetylases (HDACs) that catalyze removal of acetyl groups
from histone proteins, are strongly associated with several diseases including diabetes, yet …
from histone proteins, are strongly associated with several diseases including diabetes, yet …
RADIP technology comprehensively identifies H3K27me3-mediated RNA-chromatin interactions
X Shu, M Kato, S Takizawa, Y Suzuki, P Carninci - bioRxiv, 2024 - biorxiv.org
Many RNAs associate with chromatin, either directly or indirectly. Several technologies for
mapping regions where RNAs interact across the genome have been developed to …
mapping regions where RNAs interact across the genome have been developed to …
LncRNA Malat1 represses Th17 effector program by maintaining a critical bivalent super-enhancer and promotes intestinal inflammation
Interleukin IL-17 cytokines are central regulators of mucosal homeostasis and disease. In
mouse models of colonic tissue injury, IL-17A promotes epithelial barrier functions and …
mouse models of colonic tissue injury, IL-17A promotes epithelial barrier functions and …
Nuclear actin-dependent Meg3 expression suppresses metabolic genes by affecting the chromatin architecture at sites of elevated H3K27 acetylation levels
Three-dimensional organization of the eukaryotic genome is directly affected by the nuclear
β-actin pool that regulates enhancer function by affecting H3K27 acetylation levels. This …
β-actin pool that regulates enhancer function by affecting H3K27 acetylation levels. This …