Drug discovery is a time-consuming, high-investment, and high-risk process in traditional
drug development. Drug repositioning has become a popular strategy in recent years …

Highlights•Phenotypic screening is a renewed approach for lead discovery.•Phenotypic
screen approach may improve the success rate of drug approval.•New drug targets can be …

Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …

Metabolic reprogramming is a hallmark of cancer cells and contributes to their adaption
within the tumour microenvironment and resistance to anticancer therapies. Recently …

The current preclinical pipeline for drug discovery can be cumbersome and costly, which
limits the number of compounds that can effectively be transitioned to use as therapies …

Zebrafish represent a vertebrate model organism that has been widely, and increasingly,
employed over the last decade in the study of developmental processes, wound healing …

Glycogen phosphorylase (PG) is a key enzyme taking part in the first step of glycogenolysis.
Muscle glycogen phosphorylase (PYGM) differs from other PG isoforms in expression …

The importance of endothelial cell (EC) metabolism and its regulatory role in the angiogenic
behavior of ECs during vessel formation and in the function of different EC subtypes …

Since its identification more than 150 years ago, there has been an extensive
characterisation of glycogen metabolism and its regulatory pathways in the two main …

The zebrafish is a vertebrate model compatible with the paradigms of drug discovery. The
small size and transparency of zebrafish embryos make them amenable for the automation …