Mechanisms of translocation of ER chaperones to the cell surface and immunomodulatory roles in cancer and autoimmunity
Endoplasmic reticulum (ER) chaperones (eg, calreticulin, heat shock proteins, and
isomerases) perform a multitude of functions within the ER. However, many of these …
isomerases) perform a multitude of functions within the ER. However, many of these …
The Complement System: A Prey of Trypanosoma cruzi
KCF Lidani, L Bavia, AR Ambrosio… - Frontiers in …, 2017 - frontiersin.org
Trypanosoma cruzi is a protozoan parasite known to cause Chagas disease (CD), a
neglected sickness that affects around 6–8 million people worldwide. Originally, CD was …
neglected sickness that affects around 6–8 million people worldwide. Originally, CD was …
Antitumor mechanisms of molecules secreted by Trypanosoma cruzi in colon and breast cancer: A review
S Sadr, S Ghiassi, N Lotfalizadeh… - Anti-Cancer Agents …, 2023 - ingentaconnect.com
Background: Molecules secreted by Trypanosoma cruzi (T. cruzi) have beneficial effects on
the immune system and can fight against cancer by inhibiting the growth of tumor cells …
the immune system and can fight against cancer by inhibiting the growth of tumor cells …
Parasites as potential targets for cancer immunotherapy
M Yousefi, M Akbari, M Hadipour, AB Dehkordi… - Journal of Cancer …, 2023 - Springer
Parasites and cancers have some common antigens. Much scientific evidence in the human
population, animal models, and in vitro experiments exhibit that parasites have significant …
population, animal models, and in vitro experiments exhibit that parasites have significant …
Trypanosoma cruzi interaction with host tissues modulate the composition of large extracellular vesicles
IV Rossi, RF de Almeida, B Sabatke, LMF de Godoy… - Scientific Reports, 2024 - nature.com
Trypanosoma cruzi is the protozoan that causes Chagas disease (CD), an endemic
parasitosis in Latin America distributed around the globe. If CD is not treated in acute phase …
parasitosis in Latin America distributed around the globe. If CD is not treated in acute phase …
Identification of Differentially Expressed Proteins from Leishmania amazonensis Associated with the Loss of Virulence of the Parasites
RDM Magalhaes, MC Duarte, EC Mattos… - PLoS neglected …, 2014 - journals.plos.org
Background The present study analyzed whether or not the in vitro cultivation for long
periods of time of pre-isolated Leishmania amazonensis from lesions of chronically infected …
periods of time of pre-isolated Leishmania amazonensis from lesions of chronically infected …
Trypanosoma cruzi, Chagas disease and cancer: putting together the pieces of a complex puzzle
CD Kaufman, C Farré, L Biscari, AR Pérez… - Frontiers in Cell and …, 2023 - frontiersin.org
Considering the extensive and widespread impact on individuals, cancer can presently be
categorized as a pandemic. In many instances, the development of tumors has been linked …
categorized as a pandemic. In many instances, the development of tumors has been linked …
The many faces of parasite calreticulin
D Esperante, A Flisser, F Mendlovic - Frontiers in Immunology, 2023 - frontiersin.org
Calreticulin from parasites and its vertebrate hosts share~ 50% identity and many of its
functions are equally conserved. However, the existing amino acid differences can affect its …
functions are equally conserved. However, the existing amino acid differences can affect its …
Anti-Tumor effect of parasitic protozoans
H Ding, S Wu, Z Jin, B Zheng, Y Hu, K He, S Lu, X Zhuo - Bioengineering, 2022 - mdpi.com
The immune system may aberrantly silence when against “altered self”, which consequently
may develop into malignancies. With the development of tumor immunology and molecular …
may develop into malignancies. With the development of tumor immunology and molecular …
CaviDB: a database of cavities and their features in the structural and conformational space of proteins
Proteins are the structural, functional and evolutionary units of cells. On their surface,
proteins are shaped into numerous depressions and protrusions that provide unique …
proteins are shaped into numerous depressions and protrusions that provide unique …