Non-specificity as the sticky problem in therapeutic antibody development
Antibodies are highly potent therapeutic scaffolds with more than a hundred different
products approved on the market. Successful development of antibody-based drugs …
products approved on the market. Successful development of antibody-based drugs …
Electroneutral Polymer Nanodiscs Enable Interference‐Free Probing of Membrane Proteins in a Lipid‐Bilayer Environment
D Glueck, A Grethen, M Das, OP Mmeka, EP Patallo… - Small, 2022 - Wiley Online Library
Membrane proteins can be examined in near‐native lipid‐bilayer environments with the
advent of polymer‐encapsulated nanodiscs. These nanodiscs self‐assemble directly from …
advent of polymer‐encapsulated nanodiscs. These nanodiscs self‐assemble directly from …
High titers of low affinity antibodies in COVID-19 patients are associated with disease severity
J Hendriks, R Schasfoort, M Koerselman… - Frontiers in …, 2022 - frontiersin.org
Background Almost 2 years from the beginning of the coronavirus disease 2019 (COVID-19)
pandemic, there is still a lot unknown how the humoral response affects disease …
pandemic, there is still a lot unknown how the humoral response affects disease …
Safety and immunogenicity of anti-SARS-CoV-2 heterologous scheme with SOBERANA 02 and SOBERANA Plus vaccines: Phase IIb clinical trial in adults
ME Toledo-Romani, M García-Carmenate… - Med, 2022 - cell.com
Background SOBERANA 02 has been evaluated in phase I and IIa studies comparing
homologous versus heterologous schedule (this one, including SOBERANA Plus). Here, we …
homologous versus heterologous schedule (this one, including SOBERANA Plus). Here, we …
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
The clinical outcome of SARS-CoV-2 infections, which can range from asymptomatic to
lethal, is crucially shaped by the concentration of antiviral antibodies and by their affinity to …
lethal, is crucially shaped by the concentration of antiviral antibodies and by their affinity to …
Homogeneous surrogate virus neutralization assay to rapidly assess neutralization activity of anti-SARS-CoV-2 antibodies
The COVID-19 pandemic triggered the development of numerous diagnostic tools to monitor
infection and to determine immune response. Although assays to measure binding …
infection and to determine immune response. Although assays to measure binding …
[HTML][HTML] Decoy peptides effectively inhibit the binding of SARS-CoV-2 to ACE2 on oral epithelial cells
LK Loi, CC Yang, YC Lin, YF Su, YC Juan, YH Chen… - Heliyon, 2023 - cell.com
The entry of SARS-CoV-2 into host cells involves the interaction between the viral spike
protein and the human angiotensin-converting enzyme 2 (ACE2) receptor. Given that the …
protein and the human angiotensin-converting enzyme 2 (ACE2) receptor. Given that the …
Diffusional microfluidics for protein analysis
Wastewater-based epidemiology (WBE) is an emerging tool to monitor public health and the
outbreak of infective diseases. It requires real-time information by measuring chemicals or …
outbreak of infective diseases. It requires real-time information by measuring chemicals or …
Investigation and comparison of specific antibodies' affinity interaction with SARS-CoV-2 wild-type, B. 1.1. 7, and B. 1.351 spike protein by total internal reflection …
SARS-CoV-2 vaccines provide strong protection against COVID-19. However, the
emergence of SARS-CoV-2 variants has raised concerns about the efficacy of vaccines. In …
emergence of SARS-CoV-2 variants has raised concerns about the efficacy of vaccines. In …
Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants
Summary The B. 1.1. 529 (omicron) variant has rapidly supplanted most other SARS-CoV-2
variants. Using microfluidics-based antibody affinity profiling (MAAP), we have characterized …
variants. Using microfluidics-based antibody affinity profiling (MAAP), we have characterized …