Immunity, atherosclerosis and cardiovascular disease

J Frostegård - BMC medicine, 2013 - Springer
Atherosclerosis, the major cause of cardiovascular disease (CVD), is a chronic inflammatory
condition with immune competent cells in lesions producing mainly pro-inflammatory …

Immune effector mechanisms implicated in atherosclerosis: from mice to humans

P Libby, AH Lichtman, GK Hansson - Immunity, 2013 - cell.com
According to the traditional view, atherosclerosis results from a passive buildup of
cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune …

Anti-inflammatory therapies for atherosclerosis

M Bäck, GK Hansson - Nature Reviews Cardiology, 2015 - nature.com
The view of atherosclerosis as an inflammatory disease has emerged from observations of
immune activation and inflammatory signalling in human atherosclerotic lesions, from the …

Systemic diseases caused by oral infection

X Li, KM Kolltveit, L Tronstad… - Clinical microbiology …, 2000 - Am Soc Microbiol
Recently, it has been recognized that oral infection, especially periodontitis, may affect the
course and pathogenesis of a number of systemic diseases, such as cardiovascular …

Cytokines in atherosclerosis: pathogenic and regulatory pathways

A Tedgui, Z Mallat - Physiological reviews, 2006 - journals.physiology.org
Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

Inflammation and atherosclerosis

GK Hansson, AKL Robertson… - Annu. Rev. Pathol …, 2006 - annualreviews.org
Atherosclerosis, the cause of myocardial infarction, stroke, and ischemic gangrene, is an
inflammatory disease. The atherosclerotic process is initiated when cholesterol-containing …

Innate and adaptive immunity in the pathogenesis of atherosclerosis

GK Hansson, P Libby, U Schönbeck… - Circulation research, 2002 - Am Heart Assoc
This review considers critically the evidence for the involvement of mediators of innate and
acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innate …

B cells and humoral immunity in atherosclerosis

D Tsiantoulas, CJ Diehl, JL Witztum… - Circulation research, 2014 - Am Heart Assoc
Insights into the important contribution of inflammation and immune functions in the
development and progression of atherosclerosis have greatly improved our understanding …

Systemic lupus erythematosus and cardiovascular disease

J Frostegård - Journal of Internal Medicine, 2023 - Wiley Online Library
The prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment
and care, but cardiovascular disease (CVD) still remains an important clinical problem, since …

Immune mechanisms in atherosclerosis

GK Hansson - Arteriosclerosis, thrombosis, and vascular biology, 2001 - Am Heart Assoc
Atherosclerosis is an inflammatory disease. Its lesions are filled with immune cells that can
orchestrate and effect inflammatory responses. In fact, the first lesions of atherosclerosis …