Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

AB Kunnumakkara, D Bordoloi… - British journal of …, 2017 - Wiley Online Library
Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), which is
chemically known as diferuloylmethane, was first isolated exactly two centuries ago in 1815 …

Genetic and epigenetic etiology of inflammatory bowel disease: An update

S Jarmakiewicz-Czaja, M Zielińska, A Sokal, R Filip - Genes, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic disease with periods of exacerbation and
remission of the disease. The etiology of IBD is not fully understood. Many studies point to …

[HTML][HTML] Ulcerative colitis: Gut microbiota, immunopathogenesis and application of natural products in animal models

RP do Nascimento, AP da Fonseca Machado, J Galvez… - Life sciences, 2020 - Elsevier
Ulcerative colitis (UC) is an inflammatory bowel disease with increasing incidence in the
world, especially in developing countries. Although knowledge of its pathogenesis has …

Mesenchymal (Stem) stromal cells based as new therapeutic alternative in inflammatory bowel disease: basic mechanisms, experimental and clinical evidence, and …

N Eiro, M Fraile, A González-Jubete… - International journal of …, 2022 - mdpi.com
Inflammatory bowel diseases (IBD) are an example of chronic diseases affecting 40% of the
population, which involved tissue damage and an inflammatory process not satisfactorily …

Current clinical developments in curcumin‐based therapeutics for cancer and chronic diseases

A Kumar, C Harsha, D Parama, S Girisa… - Phytotherapy …, 2021 - Wiley Online Library
The last decade has seen an unprecedented rise in the prevalence of chronic diseases
worldwide. Different mono‐targeted approaches have been devised to treat these multigenic …

Toward understanding microbiota homeostasis in the plant kingdom

BC Paasch, SY He - PLoS Pathogens, 2021 - journals.plos.org
A diverse community of microorganisms inhabits various parts of a plant. Recent findings
indicate that perturbations to the normal microbiota can be associated with positive and …

The roles and functions of Paneth cells in Crohn's disease: A critical review

E Yang, J Shen - Cell proliferation, 2021 - Wiley Online Library
Paneth cells (PCs) are located at the base of small intestinal crypts and secrete the α‐
defensins, human α‐defensin 5 (HD‐5) and human α‐defensin 6 (HD‐6) in response to …

Gut mucosal-associated microbiota better discloses inflammatory bowel disease differential patterns than faecal microbiota

A Altomare, L Putignani, F Del Chierico, S Cocca… - Digestive and Liver …, 2019 - Elsevier
Background Growing evidence supports the potential role of intestinal microbiota in the
pathophysiology of inflammatory bowel diseases (IBD) even if the literature does not reveal …

Susceptibility to chronic inflammation: an update

NA Nasef, S Mehta, LR Ferguson - Archives of Toxicology, 2017 - Springer
Chronic inflammation is defined by the persistence of inflammatory processes beyond their
physiological function, resulting in tissue destruction. Chronic inflammation is implicated in …

[HTML][HTML] Updated review on immune factors in pathogenesis of Crohn's disease

N Li, RH Shi - World Journal of Gastroenterology, 2018 - ncbi.nlm.nih.gov
Although the incidence of Crohn's disease (CD) in China is not as high as that in European
and American countries, there has been a clear increasing trend in recent years. Little is …