A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is
underway. Originally thought to be a uniform population that progressively loses effector …

After infection, most antigen-specific memory T cells reside in nonlymphoid tissues. Tissue-
specific programming during priming leads to directed migration of T cells to the appropriate …

Tissue-resident memory T cells (TRM cells) provide superior protection against infection in
extralymphoid tissues. Here we found that CD103+ CD8+ TRM cells developed in the skin …

Upon infection, antigen-specific CD8+ T lymphocyte responses display a highly
reproducible pattern of expansion and contraction that is thought to reflect a uniform …

The skin is the largest organ of the body. The establishment of immunological memory in the
skin is a crucial component of the adaptive immune response. Once naive T cells are …

Immunization results in the differentiation of CD8+ T cells, such that they acquire effector
abilities and convert into a memory pool. Priming of T cells takes place via an immunological …

Many studies have examined pathways controlling effector T cell differentiation, but less is
known about the fate of individual CD8+ T cells during infection. Here, we examine the …

The development of T cell memory from naive precursors is influenced by molecular cues
received during T cell activation and differentiation. In this study, we describe a novel role for …

T cell immunity is often defined in terms of memory lymphocytes that use the blood to access
a range of organs. T cells are involved in two patterns of recirculation. In one, the cells …

Domestic pigs are considered as a valuable large animal model because of their close
relation to humans in regard to anatomy, genetics and physiology. This includes their …