Schizophrenia is a complex neuropsychiatric syndrome with a heterogeneous genetic,
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …

Diffusion MRI is arguably the method of choice for characterizing white matter microstructure
in vivo. Over the typical duration of diffusion encoding, the displacement of water molecules …

Abstract Development of therapies for neurological disorders depends on our ability to non-
invasively diagnose and monitor the progression of underlying pathologies at the cellular …

The ENIGMA‐DTI (diffusion tensor imaging) workgroup supports analyses that examine the
effects of psychiatric, neurological, and developmental disorders on the white matter …

Cognitive deficits contribute to functional disability in patients with schizophrenia and may
be related to altered functional networks that serve cognition. We evaluated the integrity of …

Understanding the neuropathological underpinnings of mental disorders such as
schizophrenia, major depression, and bipolar disorder is an essential step towards the …

Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for
developing Alzheimer's disease (AD). Both SZ and AD have white matter abnormalities and …

Objective: Failure of antipsychotic medications to resolve symptoms in patients with
schizophrenia creates a clinical challenge that is known as treatment resistance. The causes …

Cognitive deficits are among the best predictors of real-world functioning in schizophrenia.
However, our understanding of how cognitive deficits relate to neuropathology and clinical …

Objectives: Cognitive dysfunction is a core symptom dimension that cuts across the
psychoses. Recent findings support classification of patients along the cognitive dimension …