Successful cell division requires the precise and timely coordination of chromosomal,
cytoskeletal and membrane trafficking events. These processes are regulated by the …

As a compartment border, the nuclear envelope (NE) needs to serve as both a protective
membrane shell for the genome and a versatile communication interface between the …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-
dependent degradation of proteins. TPD is of interest in drug development, as it can address …

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in
homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound …

Defects in the architecture or integrity of the nuclear envelope are associated with a variety
of human diseases. Micronuclei, one common nuclear aberration, are an origin for …

Summary The Cdc48 ATPase and its cofactors Ufd1/Npl4 (UN) extract polyubiquitinated
proteins from membranes or macromolecular complexes, but how they perform these …

During mitotic exit, missegregated chromosomes can recruit their own nuclear envelope
(NE) to form micronuclei (MN). MN have reduced functioning compared to primary nuclei in …

The ATPase valosin-containing protein (VCP)/p97 has emerged as a central and important
element of the ubiquitin system. Together with a network of cofactors, it regulates an ever …

The ATP-driven chaperone valosin-containing protein (VCP)/p97 governs critical steps in
ubiquitin-dependent protein quality control and intracellular signalling pathways. It …