Hallmarks of the ageing lung
S Meiners, O Eickelberg… - European Respiratory …, 2015 - Eur Respiratory Soc
Ageing is the main risk factor for major non-communicable chronic lung diseases, including
chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary …
chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary …
Senescence in COPD and its comorbidities
PJ Barnes - Annual review of physiology, 2017 - annualreviews.org
Chronic obstructive pulmonary disease (COPD) is regarded as a disease of accelerated
lung aging. This affliction shows all of the hallmarks of aging, including telomere shortening …
lung aging. This affliction shows all of the hallmarks of aging, including telomere shortening …
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
Chronic obstructive pulmonary disease is a leading global cause of morbidity and mortality
that is characterised by inexorable deterioration of small airways obstruction with …
that is characterised by inexorable deterioration of small airways obstruction with …
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
H Yao, S Chung, J Hwang… - The Journal of …, 2012 - Am Soc Clin Investig
Chronic obstructive pulmonary disease/emphysema (COPD/emphysema) is characterized
by chronic inflammation and premature lung aging. Anti-aging sirtuin 1 (SIRT1), a NAD+ …
by chronic inflammation and premature lung aging. Anti-aging sirtuin 1 (SIRT1), a NAD+ …
Targeting phosphoinositide-3-kinase-δ with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease
Y To, K Ito, Y Kizawa, M Failla, M Ito… - American journal of …, 2010 - atsjournals.org
Rationale: Patients with chronic obstructive pulmonary disease (COPD) show a poor
response to corticosteroids. This has been linked to a reduction of histone deacetylase-2 as …
response to corticosteroids. This has been linked to a reduction of histone deacetylase-2 as …
Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease
T Yoshida, RM Tuder - Physiological reviews, 2007 - journals.physiology.org
Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema,
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …
Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
Aging is a natural process characterized by progressive functional impairment and reduced
capacity to respond appropriately to environmental stimuli and injury. The incidence of two …
capacity to respond appropriately to environmental stimuli and injury. The incidence of two …
Mechanisms of development of multimorbidity in the elderly
PJ Barnes - European Respiratory Journal, 2015 - Eur Respiratory Soc
In ageing populations many patients have multiple diseases characterised by acceleration
of the normal ageing process. Better understanding of the signalling pathways and cellular …
of the normal ageing process. Better understanding of the signalling pathways and cellular …
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-κB in macrophages in vitro and in rat lungs in vivo: implications for …
SR Yang, J Wright, M Bauter… - … of Physiology-Lung …, 2007 - journals.physiology.org
The silent information regulator 2 (Sir2) family of proteins (sirtuins or SIRTs), which belong to
class III histone/protein deacetylases, have been implicated in calorie restriction, aging, and …
class III histone/protein deacetylases, have been implicated in calorie restriction, aging, and …