Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …

Skeletal muscle is the most abundant type of tissue in human body, being involved in
diverse activities and maintaining a finely tuned metabolic balance. Autophagy …

Despite the extensive genetic and phenotypic variations present in the different tumors, they
frequently share common metabolic alterations, such as autophagy. Autophagy is a self …

Immunological and inflammatory processes downstream of dystrophin deficiency as well as
metabolic abnormalities, defective autophagy, and loss of regenerative capacity all …

Autophagy classically functions as a physiological process to degrade cytoplasmic
components, protein aggregates, and/or organelles, as a mechanism for nutrient …

Asymmetrically dividing muscle stem cells in skeletal muscle give rise to committed cells,
where the myogenic determination factor Myf5 is transcriptionally activated by Pax7. This …

Autophagy is emerging as a key regulatory process during skeletal muscle development,
regeneration and homeostasis, and deregulated autophagy has been implicated in …

Mitochondrial dysfunctions are recognized as major factors for various diseases including
cancer, cardiovascular diseases, diabetes, neurological disorders, and a group of diseases …

Aging is associated with impairment of multiple organs, including skeletal muscle and heart.
In this study, we investigated whether resveratrol, an activator of an NAD+-dependent …

Duchenne muscular dystrophy (DMD) is one of the most devastating neuromuscular genetic
diseases caused by the absence of dystrophin. The continuous episodes of muscle …