Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

The initiation and maintenance of reproductive capacity in humans is dependent on pulsatile
secretion of the hypothalamic hormone GnRH. Congenital hypogonadotropic hypogonadism …

The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse
functions, including motility and epithelial permeability. Perturbations in ENS development …

During the last decade, a host of epigenetic mechanisms were found to contribute to cancer
and other human diseases. Several genomic studies have revealed that∼ 20% of …

Transposable elements, also known as transposons, are now recognized not only as
parasitic DNA, the spread of which in the genome must be controlled by the host, but also as …

Non-coding mutations at the far end of a large gene desert surrounding the SOX9 gene
result in a human craniofacial disorder called Pierre Robin sequence (PRS). Leveraging a …

Human organoid model systems lack important cell types that, in the embryo, are
incorporated into organ tissues during development. We developed an organoid assembly …

The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Summary cis-regulatory changes play a central role in morphological divergence, yet the
regulatory principles underlying emergence of human traits remain poorly understood. Here …

The division of medulloblastoma into different subgroups by microarray expression profiling
has dramatically changed our perspective of this malignant childhood brain tumour. Now …