Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders
A Newman-Tancredi, RY Depoortère… - Pharmacology & …, 2022 - Elsevier
Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted
rapidly increasing interest as a means to improve discovery of more efficacious and safer …
rapidly increasing interest as a means to improve discovery of more efficacious and safer …
Pharmacological data of cannabidiol-and cannabigerol-type phytocannabinoids acting on cannabinoid CB1, CB2 and CB1/CB2 heteromer receptors
Background Recent approved medicines whose active principles are Δ 9
Tetrahidrocannabinol (Δ 9-THC) and/or cannabidiol (CBD) open novel perspectives for …
Tetrahidrocannabinol (Δ 9-THC) and/or cannabidiol (CBD) open novel perspectives for …
Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders
R Juza, K Musilek, E Mezeiova… - Medicinal Research …, 2023 - Wiley Online Library
Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …
Recent advances in the potential of cannabinoids for neuroprotection in Alzheimer's, Parkinson's, and Huntington's diseases
Three prevalent neurodegenerative diseases, Parkinson's, Alzheimer's, and Huntington's
are in need of symptomatic relief of slowing disease progression or both. This chapter …
are in need of symptomatic relief of slowing disease progression or both. This chapter …
Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease
R Franco, R Rivas-Santisteban, M Casanovas, A Lillo… - Cells, 2020 - mdpi.com
(1) Background. N-methyl d-aspartate (NMDA) ionotropic glutamate receptor (NMDAR),
which is one of the main targets to combat Alzheimer's disease (AD), is expressed in both …
which is one of the main targets to combat Alzheimer's disease (AD), is expressed in both …
Pharmacological potential of varinic-, minor-, and acidic phytocannabinoids
While natural Δ 9-tetrahidrocannabinol (Δ 9 THC), cannabidiol (CBD), and their therapeutic
potential have been extensively researched, some cannabinoids have been less extensively …
potential have been extensively researched, some cannabinoids have been less extensively …
[HTML][HTML] Similarities and differences upon binding of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors
I Raïch, R Rivas-Santisteban, A Lillo, J Lillo… - Pharmacological …, 2021 - Elsevier
We have here assessed, using Δ 9-tetrahydrocannabinol (Δ 9-THC) for comparison, the
effect of Δ 9-tetrahydrocannabinolic acid (Δ 9-THCA) and of Δ 9-tetrahydrocannabivarin (Δ9 …
effect of Δ 9-tetrahydrocannabinolic acid (Δ 9-THCA) and of Δ 9-tetrahydrocannabivarin (Δ9 …
N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential …
R Rivas-Santisteban, A Lillo, J Lillo… - Alzheimer's Research & …, 2021 - Springer
Background The cannabinoid CB 2 receptor (CB 2 R), which is a target to afford
neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate receptors, which …
neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate receptors, which …
Historical perspectives and recent advances in small molecule ligands of selective/biased/multi-targeted μ/δ/κ opioid receptor (2019–2022)
Y He, Q Su, L Zhao, L Zhang, L Yu, J Shi - Bioorganic Chemistry, 2023 - Elsevier
The opioids have been used for more than a thousand years and are not only the most
widely prescribed drugs for moderate to severe pain and acute pain, but also the preferred …
widely prescribed drugs for moderate to severe pain and acute pain, but also the preferred …