Therapeutic monitoring of calcineurin inhibitors for the nephrologist
J Schiff, E Cole, M Cantarovich - Clinical Journal of the American …, 2007 - journals.lww.com
The calcineurin inhibitors (CNI) cyclosporine and tacrolimus remain the backbone of
immunosuppression for most kidney transplant recipients. Despite many years of …
immunosuppression for most kidney transplant recipients. Despite many years of …
Therapeutic drug monitoring of immunosuppressant drugs in clinical practice
BD Kahan, P Keown, GA Levy, A Johnston - Clinical therapeutics, 2002 - Elsevier
Background: Therapeutic drug monitoring (TDM) is essential to maintain the efficacy of many
immunosuppressant drugs while minimizing their toxicity. TDM has become more refined …
immunosuppressant drugs while minimizing their toxicity. TDM has become more refined …
Recommendations for the outpatient surveillance of renal transplant recipients
BL Kasiske, MA Vazquez, WE Harmon… - Journal of the …, 2000 - journals.lww.com
Many complications after renal transplantation can be prevented if they are detected early.
Guidelines have been developed for the prevention of diseases in the general population …
Guidelines have been developed for the prevention of diseases in the general population …
Cyclosporin: An Updated Review of the Pharmacokinetic Properties, Clinical Efficacy and Tolerability of a Microemulsion-Based Formulation (Neoral®) su1 in Organ …
CJ Dunn, AJ Wagstaff, CM Perry, GL Plosker, KL Goa - Drugs, 2001 - Springer
Cyclosporin is a lipophilic cyclic polypeptide immunosuppressant that interferes with the
activity of T cells chiefly via calcineurin inhibition. The original oil-based oral formulation of …
activity of T cells chiefly via calcineurin inhibition. The original oil-based oral formulation of …
[HTML][HTML] AUC-guided dosing of tacrolimus prevents progressive systemic overexposure in renal transplant recipients
EM Scholten, SCLM Cremers, RC Schoemaker… - Kidney international, 2005 - Elsevier
AUC-guided dosing of tacrolimus prevents progressive systemic overexposure in renal
transplant recipients. Background Tacrolimus has a narrow therapeutic window, and …
transplant recipients. Background Tacrolimus has a narrow therapeutic window, and …
Patient management by Neoral C2 monitoring: An international consensus statement1
G Levy, E Thervet, J Lake, K Uchida - Transplantation, 2002 - journals.lww.com
Patient management by Neoral C2 monitoring: An international... : Transplantation Patient
management by Neoral C2 monitoring: An international consensus statement1 : Transplantation …
management by Neoral C2 monitoring: An international consensus statement1 : Transplantation …
[PDF][PDF] Report of the first international liver transplantation society expert panel consensus conference on renal insufficiency in liver transplantation
MR Charlton, WJ Wall, AO Ojo, P Ginès… - Liver …, 2009 - Wiley Online Library
Both acute kidney injury (AKI) and chronic kidney disease (CKD) are highly prevalent in liver
transplantation, affecting 25% to 50% and 30% to 90% of recipients, respectively. The risk of …
transplantation, affecting 25% to 50% and 30% to 90% of recipients, respectively. The risk of …
CYP3A5 and MDR1 Genetic Polymorphisms and Cyclosporine Pharmacokinetics After Renal Transplantation
D Anglicheau, E Thervet, I Etienne… - Clinical …, 2004 - Wiley Online Library
Background The immunosuppressive drug cyclosporine (INN, ciclosporin), whose
pharmacokinetic characteristics vary greatly among individuals, is a substrate for …
pharmacokinetic characteristics vary greatly among individuals, is a substrate for …
Cyclosporine nephrotoxicity
A Busauschina, P Schnuelle… - Transplantation …, 2004 - Elsevier
Cyclosporine (CsA) is the current primary immunosuppressant for the prevention of allograft
rejection in solid organ transplantation. However, owing to its molecular mechanism of …
rejection in solid organ transplantation. However, owing to its molecular mechanism of …
[HTML][HTML] Evidence for the alloimmune basis and prognostic significance of Borderline T cell–mediated rejection
C Wiebe, DN Rush, IW Gibson, D Pochinco… - American journal of …, 2020 - Elsevier
Prognostic biomarkers of T cell–mediated rejection (TCMR) have not been adequately
studied in the modern era. We evaluated 803 renal transplant recipients and correlated HLA …
studied in the modern era. We evaluated 803 renal transplant recipients and correlated HLA …