Solid-state nanopore sensors

L Xue, H Yamazaki, R Ren, M Wanunu… - Nature Reviews …, 2020 - nature.com
Nanopore-based sensors have established themselves as a prominent tool for solution-
based, single-molecule analysis of the key building blocks of life, including nucleic acids …

The new era of high-throughput nanoelectrochemistry

X Xu, D Valavanis, P Ciocci, S Confederat… - Analytical …, 2023 - ACS Publications
To acquire a deeper understanding of electrochemical systems requires techniques that
address nanoscale aspects of electrochemistry, inter alia, the detection and analysis of …

In situ solid-state nanopore fabrication

JP Fried, JL Swett, BP Nadappuram, JA Mol… - Chemical Society …, 2021 - pubs.rsc.org
Nanopores in solid-state membranes are promising for a wide range of applications
including DNA sequencing, ultra-dilute analyte detection, protein analysis, and polymer data …

Nanoscale tweezers for single-cell biopsies

BP Nadappuram, P Cadinu, A Barik… - Nature …, 2019 - nature.com
Much of the functionality of multicellular systems arises from the spatial organization and
dynamic behaviours within and between cells. Current single-cell genomic methods only …

Overview of the materials design and sensing strategies of nanopore devices

L Liang, F Qin, S Wang, J Wu, R Li, Z Wang… - Coordination Chemistry …, 2023 - Elsevier
Nanopore platform holds a great fascination that attracts increasing interests in research and
leads the development of various domains. Herein we first briefly introduce the …

Label-free optical analysis of biomolecules in solid-state nanopores: toward single-molecule protein sequencing

Y Zhao, M Iarossi, AF De Fazio, JA Huang… - ACS …, 2022 - ACS Publications
Sequence identification of peptides and proteins is central to proteomics. Protein
sequencing is mainly conducted by insensitive mass spectroscopy because proteins cannot …

Real-Time Monitoring of Exosomes Secretion from Single Cell Using Dual-Nanopore Biosensors

H Zhang, X Zheng, T Zhao, Y Chen, Y Luo, Y Dong… - ACS …, 2023 - ACS Publications
Exosomes secreted from cells carry rich information from their parent cells, representing a
promising biomarker for investigation of diseases. We develop a dual-nanopore biosensor …

Development of dual-nanopore biosensors for detection of intracellular dopamine and dopamine efflux from single PC12 cell

T Zhao, JW Wang, HS Zhang, X Zheng… - Analytical …, 2022 - ACS Publications
Detection of neurotransmitters at the single-cell level is essential for understanding the
related biological processes and neurodegenerative diseases. We report a dual-nanopore …

Solid‐State Quad‐Nanopore Array for High‐Resolution Single‐Molecule Analysis and Discrimination

R Hu, R Zhu, G Wei, Z Wang, ZY Gu… - Advanced …, 2023 - Wiley Online Library
The ability to detect and distinguish biomolecules at the single‐molecule level is at the
forefront of today's biomedicine and analytical chemistry research. Increasing the dwell time …

Interfacing Aptamer-Modified Nanopipettes with Neuronal Media and Ex Vivo Brain Tissue

A Stuber, A Cavaccini, A Manole… - ACS Measurement …, 2023 - ACS Publications
Aptamer-functionalized biosensors exhibit high selectivity for monitoring neurotransmitters in
complex environments. We translated nanoscale aptamer-modified nanopipette sensors to …