Polymer-based smart drug delivery systems for skin application and demonstration of stimuli-responsiveness
L Van Gheluwe, I Chourpa, C Gaigne, E Munnier - Polymers, 2021 - mdpi.com
Progress in recent years in the field of stimuli-responsive polymers, whose properties
change depending on the intensity of a signal, permitted an increase in smart drug delivery …
change depending on the intensity of a signal, permitted an increase in smart drug delivery …
Polymer-drug conjugates: Design principles, emerging synthetic strategies and clinical overview
Adagen, an enzyme replacement treatment for adenosine deaminase deficiency, was the
first protein-polymer conjugate to be approved in early 1990 s. Post this regulatory approval …
first protein-polymer conjugate to be approved in early 1990 s. Post this regulatory approval …
Solvent induced phase inversion-based in situ forming controlled release drug delivery implants
RRS Thakur, HL McMillan, DS Jones - Journal of Controlled Release, 2014 - Elsevier
In situ forming (ISF) drug delivery implants have gained tremendous levels of interest over
the last few decades. This is due to their wide range of biomedical applications such as in …
the last few decades. This is due to their wide range of biomedical applications such as in …
Human solid tumors and clinical relevance of the enhanced permeation and retention effect: a 'golden gate'for nanomedicine in preclinical studies?
Nanocarriers passively accumulate in solid tumors through irregular wide fenestrations in
neovasculature and increased retention due to poor lymphatic drainage, a phenomenon …
neovasculature and increased retention due to poor lymphatic drainage, a phenomenon …
Polymer–drug conjugates as nano-sized medicines
Polymer Therapeutics have enormously evolved in the past decades. Several polymeric
drugs as well as polymer–protein conjugates have been in the market since the 90s, but …
drugs as well as polymer–protein conjugates have been in the market since the 90s, but …
Hydrophobically modified hydroxyethyl starch: synthesis, characterization, and aqueous self-assembly into nano-sized polymeric micelles and vesicles
Hydroxyethyl starch (HES) is a water soluble semisynthetic polysaccharide that is used as a
plasma volume expander and cryoprotectant. In order to produce a fully biodegradable …
plasma volume expander and cryoprotectant. In order to produce a fully biodegradable …
Preparation and characterization of a self-emulsifying pellet formulation
The purpose of the current study is to investigate the feasibility of producing solid self-
emulsifying pellets using the extrusion/spheronization technique. Pellets were made from a …
emulsifying pellets using the extrusion/spheronization technique. Pellets were made from a …
pH-sensitive Eudragit® L 100 nanoparticles promote cutaneous penetration and drug release on the skin
Nanoparticles (NPs) are promising carriers for dermal and transdermal drug delivery.
However, the underlying dynamics of drug release from the NPs, especially, how the …
However, the underlying dynamics of drug release from the NPs, especially, how the …
Probing of the assembly structure and dynamics within nanoparticles during interaction with blood proteins
Fully understanding the influence of blood proteins on the assembly structure and dynamics
within nanoparticles is difficult because of the complexity of the system and the difficulty in …
within nanoparticles is difficult because of the complexity of the system and the difficulty in …
[PDF][PDF] Polymer-drug conjugates: current status and future trends
From Ringsdorf's model to the clinic: current status of polymer-drug conjugates 2.1. Polymer
conjugates carrying orthodox anticancer agents 2.1. 1. Polymer-Dox conjugates 2.1. 2 …
conjugates carrying orthodox anticancer agents 2.1. 1. Polymer-Dox conjugates 2.1. 2 …