The diagnosis and management of renal cell carcinoma have changed remarkably rapidly.
Although the incidence of renal cell carcinoma has been increasing, survival has improved …

Context Once believed to represent a uniform malignant phenotype, renal cell carcinoma
(RCC) is now viewed as a diverse group of cancers that arise from the nephron. Objective …

The NCCN Guidelines for Kidney Cancer focus on the screening, diagnosis, staging,
treatment, and management of renal cell carcinoma (RCC). Patients with relapsed or stage …

The NCCN Guidelines for Kidney Cancer provide multidisciplinary recommendations for the
clinical management of patients with clear cell and non–clear cell renal carcinoma. These …

The discovery that mutations in the EGFR gene are detected in up to 50% of lung
adenocarcinoma patients, along with the development of highly efficacious epidermal …

Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of
the improvements in the life quality of patients, their effectiveness is compromised by several …

Importance Identification of patients with hereditary renal cell carcinoma (RCC) is important
for cancer screening and, in patients with advanced disease, for guiding treatment. The …

Inherited susceptibility to kidney cancer is a fascinating and complex topic. Our knowledge
about types of genetic syndromes associated with an increased risk of disease is continually …

Purpose Papillary renal-cell carcinoma type 1 (PRCC1) is associated with MET gene
alterations. Our phase II trial prospectively assessed the efficacy and safety of crizotinib in …

Renal cell carcinoma (RCC) is the most common cancer of the kidney and accounts for 2–
3% of all adult malignancies. Clear cell carcinoma represents the most common histologic …