[PDF][PDF] Lysyl oxidase (LOX) family members: rationale and their potential as therapeutic targets for liver fibrosis

W Chen, A Yang, J Jia, YV Popov, D Schuppan… - …, 2020 - Wiley Online Library
The cross‐linking of structural extracellular matrix (ECM) components, especially fibrillar
collagens and elastin, is strongly implicated in fibrosis progression and resistance to fibrosis …

Fighting the fiber: targeting collagen in lung fibrosis

CA Staab-Weijnitz - American Journal of Respiratory Cell and …, 2022 - atsjournals.org
Organ fibrosis is characterized by epithelial injury and aberrant tissue repair, where
activated effector cells, mostly fibroblasts and myofibroblasts, excessively deposit collagen …

[PDF][PDF] Lysyl oxidase‐like 4 fosters an immunosuppressive microenvironment during hepatocarcinogenesis

HY Tan, N Wang, C Zhang, YT Chan, MF Yuen… - …, 2021 - Wiley Online Library
Background and Aims Lysyl oxidase‐like 4 (LOXL4) is an amine oxidase that is primarily
involved in extracellular matrix remodeling and is highly expressed in HCC tissues, but its …

Extracellular matrix stiffness—The central cue for skin fibrosis

K Wang, D Wen, X Xu, R Zhao, F Jiang… - Frontiers in Molecular …, 2023 - frontiersin.org
Skin fibrosis is a physiopathological process featuring the excessive deposition of
extracellular matrix (ECM), which is the main architecture that provides structural support …

Association of metabolic risk factors with risks of cancer and all‐cause mortality in patients with chronic hepatitis B

YB Lee, H Moon, JH Lee, EJ Cho, SJ Yu, YJ Kim… - Hepatology, 2021 - journals.lww.com
Lysyl Oxidase‐Like 4 Fosters an Immunosuppressive Microenvir... : Hepatology Lysyl
Oxidase‐Like 4 Fosters an Immunosuppressive Microenvironment During Hepatocarcinogenesis …

COVID-19. Pandemic surgery guidance

BLDM Brücher, G Nigri, A Tinelli, J Florencio… - 4 OPEN, 2020 - iris.uniroma1.it
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts

KEC Blokland, M Nizamoglu, H Habibie… - Frontiers in …, 2022 - frontiersin.org
In fibrosis remodelling of ECM leads to changes in composition and stiffness. Such changes
can have a major impact on cell functions including proliferation, secretory profile and …

[HTML][HTML] Regulators of collagen crosslinking in developing and adult tendons

AJ Ellingson, NM Pancheri… - European cells & …, 2022 - ncbi.nlm.nih.gov
Tendons are collagen-rich musculoskeletal tissues that possess the mechanical strength
needed to transfer forces between muscles and bones. The mechanical development and …

Mast cells induce ductular reaction mimicking liver injury in mice through mast cell–derived transforming growth factor beta 1 signaling

K Kyritsi, L Kennedy, V Meadows, L Hargrove… - …, 2021 - Wiley Online Library
Background and Aims Following liver injury, mast cells (MCs) migrate into the liver and are
activated in patients with cholestasis. Inhibition of MC mediators decreases ductular reaction …

Nobiletin promotes the pyroptosis of breast cancer via regulation of miR‐200b/JAZF1 axis

JG Wang, WJ Jian, Y Li, J Zhang - The Kaohsiung journal of …, 2021 - Wiley Online Library
Nobiletin is a polymethoxylated flavone present in citrus fruits, which has been reported to
have inhibitory effects on tumorigenesis of cancers. However, the biological function of …