[PDF][PDF] Lysyl oxidase (LOX) family members: rationale and their potential as therapeutic targets for liver fibrosis
The cross‐linking of structural extracellular matrix (ECM) components, especially fibrillar
collagens and elastin, is strongly implicated in fibrosis progression and resistance to fibrosis …
collagens and elastin, is strongly implicated in fibrosis progression and resistance to fibrosis …
Fighting the fiber: targeting collagen in lung fibrosis
CA Staab-Weijnitz - American Journal of Respiratory Cell and …, 2022 - atsjournals.org
Organ fibrosis is characterized by epithelial injury and aberrant tissue repair, where
activated effector cells, mostly fibroblasts and myofibroblasts, excessively deposit collagen …
activated effector cells, mostly fibroblasts and myofibroblasts, excessively deposit collagen …
[PDF][PDF] Lysyl oxidase‐like 4 fosters an immunosuppressive microenvironment during hepatocarcinogenesis
Background and Aims Lysyl oxidase‐like 4 (LOXL4) is an amine oxidase that is primarily
involved in extracellular matrix remodeling and is highly expressed in HCC tissues, but its …
involved in extracellular matrix remodeling and is highly expressed in HCC tissues, but its …
Extracellular matrix stiffness—The central cue for skin fibrosis
K Wang, D Wen, X Xu, R Zhao, F Jiang… - Frontiers in Molecular …, 2023 - frontiersin.org
Skin fibrosis is a physiopathological process featuring the excessive deposition of
extracellular matrix (ECM), which is the main architecture that provides structural support …
extracellular matrix (ECM), which is the main architecture that provides structural support …
Association of metabolic risk factors with risks of cancer and all‐cause mortality in patients with chronic hepatitis B
Lysyl Oxidase‐Like 4 Fosters an Immunosuppressive Microenvir... : Hepatology Lysyl
Oxidase‐Like 4 Fosters an Immunosuppressive Microenvironment During Hepatocarcinogenesis …
Oxidase‐Like 4 Fosters an Immunosuppressive Microenvironment During Hepatocarcinogenesis …
COVID-19. Pandemic surgery guidance
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …
protecting patients as well as healthcare staff and hereby provide this Guidance to address …
Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts
In fibrosis remodelling of ECM leads to changes in composition and stiffness. Such changes
can have a major impact on cell functions including proliferation, secretory profile and …
can have a major impact on cell functions including proliferation, secretory profile and …
[HTML][HTML] Regulators of collagen crosslinking in developing and adult tendons
AJ Ellingson, NM Pancheri… - European cells & …, 2022 - ncbi.nlm.nih.gov
Tendons are collagen-rich musculoskeletal tissues that possess the mechanical strength
needed to transfer forces between muscles and bones. The mechanical development and …
needed to transfer forces between muscles and bones. The mechanical development and …
Mast cells induce ductular reaction mimicking liver injury in mice through mast cell–derived transforming growth factor beta 1 signaling
K Kyritsi, L Kennedy, V Meadows, L Hargrove… - …, 2021 - Wiley Online Library
Background and Aims Following liver injury, mast cells (MCs) migrate into the liver and are
activated in patients with cholestasis. Inhibition of MC mediators decreases ductular reaction …
activated in patients with cholestasis. Inhibition of MC mediators decreases ductular reaction …
Nobiletin promotes the pyroptosis of breast cancer via regulation of miR‐200b/JAZF1 axis
JG Wang, WJ Jian, Y Li, J Zhang - The Kaohsiung journal of …, 2021 - Wiley Online Library
Nobiletin is a polymethoxylated flavone present in citrus fruits, which has been reported to
have inhibitory effects on tumorigenesis of cancers. However, the biological function of …
have inhibitory effects on tumorigenesis of cancers. However, the biological function of …