The tumor microenvironment (TME) is composed of many different cellular and acellular
components that together drive tumor growth, invasion, metastasis, and response to …

Triple negative breast cancer (TNBC) continues to be the subtype of breast cancer with the
highest rates of recurrence and mortality. The lack of expression of targetable proteins such …

Solid tumours comprise many different cell types organized in spatially structured
arrangements, with substantial intratumour and intertumour heterogeneity. Advances in …

The rapidly developing spatial omics generated datasets with diverse scales and modalities.
However, most existing methods focus on modeling dynamics of single cells while ignore …

Advances in multiplex histology allow surveying millions of cells, dozens of cell types, and
up to thousands of phenotypes within the spatial context of tissue sections. This leads to a …

Triple-negative breast cancer (TNBC) patients have a poor prognosis and few treatment
options. Mouse models of TNBC are important for development of new therapies, however …

Antigen-specific T cells traffic to, are influenced by, and create unique cellular
microenvironments. Here we characterize these microenvironments over time with …

Immune checkpoint inhibitors (ICIs) are an expanding class of immunotherapeutic agents
with the potential to cure cancer. Despite the outstanding clinical response in patient …

Since its introduction into the field of oncology, deep learning (DL) has impacted clinical
discoveries and biomarker predictions. DL-driven discoveries and predictions in oncology …

In the field of immunology, a systems biology approach is crucial to understanding the
immune response to infection and vaccination considering the complex interplay between …