Antimicrobial stewardship programs in hospitals seek to optimize antimicrobial prescribing
in order to improve individual patient care as well as reduce hospital costs and slow the …

Within a susceptible wild-type population, a small fraction of cells, even< 10− 9, is not
affected when challenged by an antimicrobial agent. This subpopulation has mutations that …

Antibiotics have dramatically changed the prognoses of patients with severe infectious
diseases over the past 50 years. However, the emergence and dissemination of resistant …

An increasing variety of indicators of antimicrobial usage has become available in human
and veterinary medicine, with no consensus on the most appropriate indicators to be used …

Background. Therapeutic antibiotic use in humans is a significant driver of antibiotic
resistance. The seasonal effect of antibiotic use on antibiotic resistance has been poorly …

Pan-European surveillance of bacteraemia caused by methicillin-resistant Staphylococcus
aureus (MRSA) shows it to be a problem affecting all European countries, although there is …

Linezolid has been widely used in the treatment of Gram-positive infections for more than a
decade. It is unique amongst antibiotics active against most multiply-resistant Gram-positive …

The worldwide epidemic of antibiotic resistance is in danger of ending the golden age of
antibiotic therapy. Resistance impacts on all areas of medicine, and is making successful …

Surveillance of bacteraemia caused by methicillin-resistant Staphylococcus aureus (MRSA)
in the UK has involved collection of data from hospital microbiology laboratories via several …

Objectives To evaluate the impact of a high-risk antibiotic stewardship programme on
reducing antibiotic use and on hospital Clostridium difficile infection (CDI) incidence rates. A …