Brain aging mechanisms with mechanical manifestations

Y Blinkouskaya, A Caçoilo, T Gollamudi… - Mechanisms of ageing …, 2021 - Elsevier
Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

An analytical review of the numerical methods used for finite element modeling of traumatic brain injury

JS Giudice, W Zeng, T Wu, A Alshareef… - Annals of biomedical …, 2019 - Springer
Dozens of finite element models of the human brain have been developed for providing
insight into the mechanical response of the brain during impact. Many models used in …

Validation and comparison of instrumented mouthguards for measuring head kinematics and assessing brain deformation in football impacts

Y Liu, AG Domel, SA Yousefsani, J Kondic… - Annals of Biomedical …, 2020 - Springer
Because of the rigid coupling between the upper dentition and the skull, instrumented
mouthguards have been shown to be a viable way of measuring head impact kinematics for …

An anatomically detailed and personalizable head injury model: Significance of brain and white matter tract morphological variability on strain

X Li, Z Zhou, S Kleiven - Biomechanics and modeling in mechanobiology, 2021 - Springer
Finite element head (FE) models are important numerical tools to study head injuries and
develop protection systems. The generation of anatomically accurate and subject-specific …

Finite element methods in human head impact simulations: a review

A Madhukar, M Ostoja-Starzewski - Annals of biomedical engineering, 2019 - Springer
Head impacts leading to traumatic brain injury (TBI) present a major health risk today,
projected to become the third leading cause of death by 2020. While finite element (FE) …

Embedded axonal fiber tracts improve finite element model predictions of traumatic brain injury

M Hajiaghamemar, T Wu, MB Panzer… - … and modeling in …, 2020 - Springer
With the growing rate of traumatic brain injury (TBI), there is an increasing interest in
validated tools to predict and prevent brain injuries. Finite element models (FEM) are …

A reanalysis of football impact reconstructions for head kinematics and finite element modeling

EJ Sanchez, LF Gabler, AB Good, JR Funk… - Clinical …, 2019 - Elsevier
Background Head kinematics generated by laboratory reconstructions of professional
football helmet impacts have been applied to computational models to study the …

In vivo estimates of axonal stretch and 3D brain deformation during mild head impact

AK Knutsen, AD Gomez, M Gangolli, WT Wang… - Brain multiphysics, 2020 - Elsevier
The rapid deformation of brain tissue in response to head impact can lead to traumatic brain
injury. In vivo measurements of brain deformation during non-injurious head impacts are …

MR Imaging of Human Brain Mechanics In Vivo: New Measurements to Facilitate the Development of Computational Models of Brain Injury

PV Bayly, A Alshareef, AK Knutsen, K Upadhyay… - Annals of biomedical …, 2021 - Springer
Computational models of the brain and its biomechanical response to skull accelerations
are important tools for understanding and predicting traumatic brain injuries (TBIs) …

Multi-scale white matter tract embedded brain finite element model predicts the location of traumatic diffuse axonal injury

M Hajiaghamemar, SS Margulies - Journal of Neurotrauma, 2021 - liebertpub.com
Finite element models (FEMs) are used increasingly in the traumatic brain injury (TBI) field to
provide an estimation of tissue responses and predict the probability of sustaining TBI after a …