Sulfur fluoride exchange (SuFEx), a new generation of click chemistry, was first presented by
Sharpless, Dong and co-workers in 2014. Owing to the high stability and yet efficient …

Click chemistry is a conceptual strategy to rapidly synthesize and discover functional
molecules. Sulfur fluoride exchange (SuFEx) is a click reaction that has revolutionized …

Bioorthogonal chemistry provides a new avenue for disease treatment by generating
therapeutic agents in situ. However, two crucial issues have to be considered for future …

Covalent inhibitors and other types of covalent modalities have seen a revival in the past two
decades, with a variety of new targeted covalent drugs having been approved in recent …

SuFEx click chemistry has been a method for the rapid synthesis of functional molecules
with desirable properties. Here, we demonstrated a workflow that allows for in situ synthesis …

Phosphorus fluoride exchange (PFEx), recently debuted in small molecules, represents the
forefront of click chemistry. To explore PFEx's potential in biological settings, we developed …

Sulfur (VI) fluoride motifs are important entities in organic chemistry. Typically, their
syntheses involve the corresponding chlorides, which are often difficult to prepare and …

A practical synthetic method for the synthesis of vinyl sulfonyl fluorides through copper-
promoted direct fluorosulfonylation has been developed. The reaction of the vinylboronic …

Of the targets for HIV-1 therapeutics, the capsid core is a relatively unexploited but alluring
drug target due to its indispensable roles throughout virus replication. Because of this, we …

SuFEx click chemistry demonstrates remarkable molecular assembly capabilities. However,
the effective utilization of alkyl sulfonyl fluoride hubs in SuFEx chemistry, particularly in …