Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

▪ Abstract The energy landscape theory of protein folding is a statistical description of a
protein's potential surface. It assumes that folding occurs through organizing an ensemble of …

A grand challenge in the field of structural biology is to design and engineer proteins that
exhibit targeted functions. Although much success on this front has been achieved, design …

Fluorescence arguably constitutes the most widely used experimental approach in the field
of protein folding. Hence, any review of the use of fluorescence to probe protein stability and …

An implementation of classical molecular dynamics on parallel computers of increased
efficiency has enabled a simulation of protein folding with explicit representation of water for …

The mechanism of protein folding (represented schematically below) is one of the most
fascinating problems in the field of chemical reactions. This review presents the progess …

Folding funnels have been the focus of considerable attention during the last few years.
These have mostly been discussed in the general context of the theory of protein folding …

We investigated the fusion of high-speed liquid droplets as a way to record the kinetics of
liquid-phase chemical reactions on the order of microseconds. Two streams of micrometer …

Discussions of biochemical fluorescence frequently start with the subject of protein
fluorescence. This is because, among biopolymers, proteins are unique in displaying useful …

Single-molecule measurements provide unique information on heterogeneous populations
of molecules: They give access to the complete distribution of observables (rather than only …