Metabologenomics integrates metabolomics with other omics data types to comprehensively
study the genetic and environmental factors that influence metabolism. These multi-omics …

Gene therapy is a promising therapeutic approach for genetic and acquired diseases
nowadays. Among DNA delivery vectors, recombinant adeno‐associated virus (rAAV) is one …

Genome-scale network reconstructions have helped uncover the molecular basis of
metabolism. Here we present Recon3D, a computational resource that includes three …

Introduction The human genome-scale metabolic reconstruction details all known metabolic
reactions occurring in humans, and thereby holds substantial promise for studying complex …

Chinese hamster ovary (CHO) cells dominate biotherapeutic protein production and are
widely used in mammalian cell line engineering research. To elucidate metabolic …

Genome-scale models of metabolism can illuminate the molecular basis of cell phenotypes.
Since some enzymes are only active in specific cell types, several algorithms use omics data …

Gas fermentation using acetogenic bacteria offers a promising route for the sustainable
production of low carbon fuels and commodity chemicals from abundant, inexpensive C1 …

Abstract In mammalian cells,> 25% of synthesized proteins are exported through the
secretory pathway. The pathway complexity, however, obfuscates its impact on the secretion …

In cell and molecular biology, metabolism is the only system that can be fully simulated at
genome scale. Metabolic systems biology offers powerful abstraction tools to simulate all …

Energy metabolism is central to cellular biology. Thus, genome-scale models of
heterotrophic unicellular species must account appropriately for the utilization of external …