Inflammatory cytokines and Alzheimer's disease: a review from the perspective of genetic polymorphisms

F Su, F Bai, Z Zhang - Neuroscience bulletin, 2016 - Springer
Neuroinflammatory processes are a central feature of Alzheimer's disease (AD) in which
microglia are over-activated, resulting in the increased production of pro-inflammatory …

Comorbidity of osteoporosis and Alzheimer's disease: IsAKT-ing on cellular glucose uptake the missing link?

K Fehsel, J Christl - Ageing Research Reviews, 2022 - Elsevier
Osteoporosis and Alzheimer's disease (AD) are both degenerative diseases. Osteoporosis
often proceeds cognitive deficits, and multiple studies have revealed common triggers that …

IL-1β, IL-6, IL-10, and TNF α single nucleotide polymorphisms in human influence the susceptibility to Alzheimer's disease pathology

M Babić Leko, M Nikolac Perković… - Journal of …, 2020 - content.iospress.com
Background: Neuroinflammation plays an important role in Alzheimer's disease (AD). During
this process, activated microglia release pro-inflammatory cytokines such as interleukin (IL) …

The Role of IL-6 in Neurodegenerative Disorders

C Shan, C Zhang, C Zhang - Neurochemical Research, 2024 - Springer
Abstract “Neurodegenerative disorder” is an umbrella term for a group of fatal progressive
neurological illnesses characterized by neuronal loss and inflammation. Interleukin-6 (IL-6) …

Pharmacogenetic analyses of therapeutic effects of lipophilic statins on cognitive and functional changes in Alzheimer's disease

FF de Oliveira, PHF Bertolucci… - Journal of …, 2022 - content.iospress.com
Background: Pharmacogenetic effects of statins on clinical changes in Alzheimer's disease
(AD) could be mediated by epistatic interactions among relevant genetic variants involved in …

[HTML][HTML] Genetic polymorphisms of interleukin genes and the risk of Alzheimer's disease: An update meta-analysis

MJ Mun, JH Kim, JY Choi, WC Jang - Meta gene, 2016 - Elsevier
Objectives Recently, several meta-analyses have reported an association between
interleukin (IL) gene polymorphisms and the risk of Alzheimer's disease (AD). Several further …

Genetic variants associated with acne vulgaris

H Zhang, Z Zhang - International Journal of General Medicine, 2023 - Taylor & Francis
Acne vulgaris (AV) ranks among the common chronic inflammatory disorders that impact the
sebaceous components of hair follicles. Acne vulgaris is characterised by cardinal …

[PDF][PDF] IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population

GQ Sun, GD Wu, Y Meng, B Du, YB Li - Genet Mol Res, 2014 - funpecrp.com.br
We investigated the relationships between single nucleotide polymorphisms (SNPs) of the
interleukin (IL)-6 gene 174 G> C (rs1800795), 572 G> C (rs1800796), and 597 G/A …

CDK5 and MAPT gene expression in Alzheimer's disease brain samples

JT Fukasawa, RW de Labio… - Current Alzheimer …, 2018 - benthamdirect.com
Background: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by
extracellular amyloid plaque and neurofibrillary tangles in the brain. Studies have shown …

Untangling huge literature to disinter genetic underpinnings of Alzheimer's disease: A systematic review and meta-analysis

HS GNS, VLP Marise, KS Satish, AV Yergolkar… - Ageing Research …, 2021 - Elsevier
Drug discovery for Alzheimer's Disease (AD) is channeled towards unravelling key disease
specific drug targets/genes to predict promising therapeutic candidates. Though enormous …