HUH endonucleases are numerous and widespread in all three domains of life. The major
function of these enzymes is processing a range of mobile genetic elements by catalysing …

Transposons are ubiquitous in prokaryotic and eukaryotic organisms and are major
determinants of genome structure. Transposition—the movement of discrete segments of …

Clustered regularly interspaced palindromic repeats (CRISPRs) and the CRISPR-
associated (Cas) nuclease protect bacteria and archeae from foreign DNA by site-specific …

All eukaryotic DNA transposons reported so far belong to a single category of elements
transposed by the so-called “cut-and-paste” mechanism. Here, we report a previously …

In the late 1950s, a number of laboratories took up the study of plasmids once the discovery
was made that extrachromosomal antibiotic resistance (R) factors are the responsible …

Rolling-circle eukaryotic transposons, known as Helitron transposons, were first discovered
in plants (Arabidopsis thaliana and Oryza sativa) and in the nematode Caenorhabditis …

Geminiviruses encode a replication initiator protein, Rep, which binds in a sequence-
specific fashion to iterated DNA motifs (iterons) functioning as essential elements for virus …

Bacteriophages (prokaryotic viruses) are favourite model systems to study DNA replication
in prokaryotes, and provide examples for every theoretically possible replication …

This review provides a historical perspective of the major findings that contributed to our
current understanding of plasmid rolling-circle (RC) replication. Rolling-circle-replicating …

Sourdough has played a significant role in human nutrition and culture for thousands of
years and is still of eminent importance for human diet and the bakery industry. Lactobacillus …