HIV-1 drug resistance and resistance testing

DS Clutter, MR Jordan, S Bertagnolio… - Infection, Genetics and …, 2016 - Elsevier
The global scale-up of antiretroviral (ARV) therapy (ART) has led to dramatic reductions in
HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential …

HIV-1 antiretroviral resistance: scientific principles and clinical applications

MW Tang, RW Shafer - Drugs, 2012 - Springer
The efficacy of an antiretroviral (ARV) treatment regimen depends on the activity of the
regimen's individual ARV drugs and the number of HIV-1 mutations required for the …

Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society–USA panel

MA Thompson, JA Aberg, JF Hoy, A Telenti, C Benson… - Jama, 2012 - jamanetwork.com
Context New trial data and drug regimens that have become available in the last 2 years
warrant an update to guidelines for antiretroviral therapy (ART) in human immunodeficiency …

Global trends in antiretroviral resistance in treatment-naive individuals with HIV after rollout of antiretroviral treatment in resource-limited settings: a global …

RK Gupta, MR Jordan, BJ Sultan, A Hill, DHJ Davis… - The Lancet, 2012 - thelancet.com
Background The emergence and spread of high levels of HIV-1 drug resistance in resource-
limited settings where combination antiretroviral treatment has been scaled up could …

Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society–USA Panel

HF Günthard, JA Aberg, JJ Eron, JF Hoy, A Telenti… - Jama, 2014 - jamanetwork.com
Importance New data and antiretroviral regimens expand treatment choices in resource-rich
settings and warrant an update of recommendations to treat adults infected with human …

Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient-and sequence …

SY Rhee, JL Blanco, MR Jordan, J Taylor… - PLoS …, 2015 - journals.plos.org
Background Regional and subtype-specific mutational patterns of HIV-1 transmitted drug
resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines …

British HIV Association guidelines for the treatment of HIV‐1‐positive adults with antiretroviral therapy 2012 (Updated November 2013. All changed text is cast in …

Writing Group, I Williams, D Churchill… - HIV …, 2014 - Wiley Online Library
1.4 Resource use 1.5 Implications for research 1.6 References 2.0 Recommendations and
auditable outcomes 2.1 Recommendations (GRADE) 2.1. 1 Patient involvement in decision …

Transmission of HIV drug resistance and the predicted effect on current first-line regimens in Europe

LM Hofstra, N Sauvageot, J Albert… - Clinical infectious …, 2016 - academic.oup.com
Background. Numerous studies have shown that baseline drug resistance patterns may
influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug …

HIV drug resistance: problems and perspectives

PS Pennings - Infectious disease reports, 2013 - mdpi.com
Access to combination antiretroviral treatment (ART) has improved greatly over recent years.
At the end of 2011, more than eight million HIV-infected people were receiving ART in low …

HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study

RL Hamers, CL Wallis, C Kityo, M Siwale… - The Lancet infectious …, 2011 - thelancet.com
Background There are few data on the epidemiology of primary HIV-1 drug resistance after
the roll-out of antiretroviral treatment (ART) in sub-Saharan Africa. We aimed to assess the …