Biocompatibility of resorbable polymers: a historical perspective and framework for the future

D Pappalardo, T Mathisen… - Biomacromolecules, 2019 - ACS Publications
The history of resorbable polymers containing glycolide, lactide, ε-caprolactone and
trimethylene carbonate, with a special emphasis being placed on the time frame of the …

Biomimetic architectures for peripheral nerve repair: a review of biofabrication strategies

PA Wieringa, AR Gonçalves de Pinho… - Advanced …, 2018 - Wiley Online Library
Biofabrication techniques have endeavored to improve the regeneration of the peripheral
nervous system (PNS), but nothing has surpassed the performance of current clinical …

Evaluation of biocompatibility of polypyrrole in vitro and in vivo

X Wang, X Gu, C Yuan, S Chen… - … Research Part A: An …, 2004 - Wiley Online Library
In this study, the biocompatibility of the electrically conductive polymer polypyrrole (PPy) with
nerve tissue was evaluated in vitro and in vivo. The extraction solution of PPy powder, which …

Dog sciatic nerve regeneration across a 30-mm defect bridged by a chitosan/PGA artificial nerve graft

X Wang, W Hu, Y Cao, J Yao, J Wu, X Gu - Brain, 2005 - academic.oup.com
We have developed a dual-component artificial nerve graft comprising an outer microporous
conduit of chitosan and internal oriented filaments of polyglycolic acid (PGA). The novel graft …

Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration

MS Widmer, PK Gupta, L Lu, RK Meszlenyi… - Biomaterials, 1998 - Elsevier
We have fabricated porous, biodegradable tubular conduits for guided tissue regeneration
using a combined solvent casting and extrusion technique. The biodegradable polymers …

Guided neurite elongation and Schwann cell invasion into magnetically aligned collagen in simulated peripheral nerve regeneration

N Dubey, PC Letourneau, RT Tranquillo - Experimental neurology, 1999 - Elsevier
High-strength magnetic fields were used to align collagen gel formed into 4-mm-diameter
rods during the self-assembly of type I collagen monomers into fibrils. We developed an in …

Methods to evaluate functional nerve recovery in adult rats: walking track analysis, video analysis and the withdrawal reflex

JR Dijkstra, MF Meek, PH Robinson… - Journal of neuroscience …, 2000 - Elsevier
The aim of this study was to compare different methods for the evaluation of functional nerve
recovery. Three groups of adult male Wistar rats were studied. In group A, a 12-mm gap …

Advances and applications of biodegradable elastomers in regenerative medicine

MC Serrano, EJ Chung… - Advanced Functional …, 2010 - Wiley Online Library
When elastomers were first proposed as useful materials for regenerative medicine a few
decades ago, their high versatility and suitability for a diverse and wide range of in vivo …

Spider silk constructs enhance axonal regeneration and remyelination in long nerve defects in sheep

C Radtke, C Allmeling, KH Waldmann, K Reimers… - PloS one, 2011 - journals.plos.org
Background Surgical reapposition of peripheral nerve results in some axonal regeneration
and functional recovery, but the clinical outcome in long distance nerve defects is …

Neuronal contact guidance in magnetically aligned fibrin gels: effect of variation in gel mechano-structural properties

N Dubey, PC Letourneau, RT Tranquillo - Biomaterials, 2001 - Elsevier
Neurite outgrowth from chick dorsal root ganglia entrapped in isotropic and magnetically
aligned fibrin gels was studied, and the dependence on the diameter of the fibrin fibrils was …