The MCS initiative was first introduced in 2013. Since then, two MCS papers have been
published: the first proposing a structured approach to consider the impact of drug …

Utilising three artificial intelligence (AI)/machine learning (ML) tools, this study explores the
prediction of fill level in inclined linear blenders at steady state by mapping a wide range of …

For the continuous operation of granulation, which is a standard unit operation in powder
processing to modify the particle size, the use of twin-screw machines was established as …

The current paper shows how excipient properties impact the process parameters and the
final tablet properties in a fully integrated continuous direct compression line. Blend …

Transferring an existing marketed pharmaceutical product from batch to continuous
manufacturing (CM) without changes in regulatory registration is a challenging task in the …

Continuous melt granulation with a planetary roller granulator is a new continuous method
based on the orbital motion of planetary spindles driven by a rotating central spindle in a …

This feasibility study evaluates a cleaning process designed to avoid the use of detergents
and reduce operator exposure to the active pharmaceutical ingredient (API). The continuous …

In this study, an in-depth comparison was made between batch and continuous direct
compression using similar compression set-ups. The overall material processability and final …

The statistical discipline of time series analysis excels at modeling and forecasting the
dynamics of complex systems that exhibit non-random correlations between successive …

Квалификационная работа содержит 42 страницы, 3 таблицы, 12 рисунков, список
литератури з 54 наименований. С целью разработки состава и технологии …