Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregation
Protein and peptides are converted from their soluble forms into highly ordered fibrillar
aggregates under various conditions inside the cell. Such transitions confer diverse …
aggregates under various conditions inside the cell. Such transitions confer diverse …
Protein folding, misfolding and aggregation: A tale of constructive to destructive assembly
The newly synthesized unfolded polypeptide attains its functional and unique three-
dimensional conformation through the process of protein folding for which several models …
dimensional conformation through the process of protein folding for which several models …
Correlating Bromelain's activity with its structure and active-site dynamics and the medium's physical properties in a hydrated deep eutectic solvent
Deep eutectic solvents (DESs) are emerging as new media of choice for biocatalysis due to
their environmentally friendly nature, fine-tunability, and potential biocompatibility. This work …
their environmentally friendly nature, fine-tunability, and potential biocompatibility. This work …
Investigating the inhibitory effects of entacapone on amyloid fibril formation of human lysozyme
L Jin, W Gao, C Liu, N Zhang, S Mukherjee… - International Journal of …, 2020 - Elsevier
The misfolding of soluble protein to amyloid fibers or oligomers leads to cell membrane
rupture, cell death, and a variety of amyloid-related diseases. Hence, inhibition of protein …
rupture, cell death, and a variety of amyloid-related diseases. Hence, inhibition of protein …
Binding of anti-cardiovascular drug to serum albumin: an insight in the light of spectroscopic and computational approaches
Isoprenaline hydrochloride is a potential cardiovascular drug helps in the smooth
functioning of the heart muscles. So, we have performed the binding study of ISO with BSA …
functioning of the heart muscles. So, we have performed the binding study of ISO with BSA …
Polyols (Glycerol and Ethylene glycol) mediated amorphous aggregate inhibition and secondary structure restoration of metalloproteinase-conalbumin (ovotransferrin)
Under physical or chemical stress, proteins tend to form aggregates either highly ordered
(amyloid) or unordered (amorphous) causing many pathological disorders in human and …
(amyloid) or unordered (amorphous) causing many pathological disorders in human and …
An intermittent amyloid phase found in gemini (G5 and G6) surfactant induced β-sheet to α-helix transition in concanavalin A protein
Surfactant-induced amyloid fibrillation has many implications in laboratory and industry.
Previously, cetyltrimethylammonium bromide (CTAB; C 19 H 42 BrN) induced amyloid …
Previously, cetyltrimethylammonium bromide (CTAB; C 19 H 42 BrN) induced amyloid …
An in-vitro elucidation of inhibitory potential of carminic acid: possible therapeutic approach for neurodegenerative diseases
Protein misfolding leads to several human pathologies. So far, there has not been much
success on the remediations of these protein conformational disorders. Since these …
success on the remediations of these protein conformational disorders. Since these …
Preheat-stabilized pea proteins with anti-aggregation properties
Solution stability of food proteins is a crucial factor determining their shelf-life and sensory
properties; yet to obtain stable protein products such as beverages is generally challenged …
properties; yet to obtain stable protein products such as beverages is generally challenged …
Elucidating the interaction of clofazimine with bovine liver catalase; a comprehensive spectroscopic and molecular docking approach
Nowadays, understanding of interface between protein and drugs has become an active
research area of interest. These types of interactions provide structural guidelines in drug …
research area of interest. These types of interactions provide structural guidelines in drug …