Abstract Uridine diphosphate-3-O-(hydroxymyristoyl)-N-acetylglucosamine deacetylase
(LpxC) is a metalloenzyme with zinc ions as cofactors and is a key enzyme in the essential …

ABSTRACT Introduction: The Zn2+-dependent deacetylase LpxC is an essential enzyme of
lipid A biosynthesis in Gram-negative bacteria and a promising target for the development of …

Rapid, sensitive, simultaneous quantification of multiple biomarkers in point-of-care (POC)
settings could improve the diagnosis and management of sepsis, a common, potentially life …

Introduction Severe sepsis and septic shock (SS) are time-critical medical emergencies that
affect millions of people in the world. Earlier administration of antibiotics has been shown to …

Rationale: Sepsis is a systemic inflammatory condition resulting from bacterial infections; it
has a high mortality rate and limited therapeutic options. Despite extensive research into the …

Introduction Sepsis is a complex inflammatory disorder believed to originate from an
infection by any types of microbes and/or their products. It is the leading cause of death in …

Objective Early sepsis recognition and treatment are essential in order to reduce the burden
of disease. Initial assessment of patients with infection is often undertaken by ED nurses and …

Results: Sepsis increased the total number of macrophages and their M2 subtype in (VAT),
whereas obesity did not seem to affect the concentration of macrophages in fat. Obesity …

Introduction The prognostic evaluation of the septic patient has recently been enriched by
some predictive indices such as albumin concentration, lactate/albumin ratio (LAR) and C …

The bacterial enzyme UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase
(LpxC), catalyzing the first committed step of lipid A biosynthesis, represents a promising …