Bone turnover markers (BTMs) are used widely, in both research and clinical practice. In the
last 20 years, much experience has been gained in measurement and interpretation of these …

Spaceflight and its associated stressors, such as microgravity, radiation exposure,
confinement, circadian derailment and disruptive workloads represent an unprecedented …

Disuse and aging are known risk factors associated with low bone mass and quality
deterioration, resulting in increased fracture risk. Indeed, current and emerging evidence …

Prolonged bed rest and lifelong physical inactivity cause deleterious effects to multiple
physiological systems that appear to hasten aging processes. Many such changes are …

Space travelers are exposed to microgravity (µ g), which induces enhanced bone loss
compared to the age-related bone loss on Earth. Microgravity promotes an increased bone …

Context Sleep abnormalities are associated with low bone mineral density. Underlying
mechanisms are unknown. Objective Investigate the impact of sleep restriction with …

Objective: to describe the deleterious effects of prolonged bed rest on the body systems of
the elderly. Method: an integrative-narrative review was carried out, with the following …

Key points Disuse in older adults can critically decrease lower limb muscle power, leading to
compromised mobility and overall quality of life. We studied how muscle power and its …

The dissociation of bone formation and resorption is an important physiological process
during spaceflight. It also occurs during local skeletal unloading or immobilization, such as …

Bone turnover markers (BTMs) have been developed many years ago to study, in
combination with imaging techniques, bone remodeling in adults. In children and …