The concept of multi-action octahedral platinum (IV) complexes is based on the rational
derivatization of anticancer square-planar platinum (II) compounds (eg, cisplatin or …

Platinum complexes are potential antitumor drugs in chemotherapy. Their impact on tumor
treatment could be greatly strengthened by combining with immunotherapy. Increasing …

To develop next-generation metal drugs with high efficiency and low toxicity for targeting
inhibition of gastric tumor growth and metastasis, we not only optimized a series of …

Lactate dehydrogenase (LDH) is a key enzyme involved in the process of glycolysis,
assisting cancer cells to take in glucose and generate lactate, as well as to suppress and …

Platinum-based chemotherapeutics are widely used for cancer treatment but are frequently
limited because of dosage-dependent side effects and drug resistance. To attenuate these …

Abstract Development of resistance to cisplatin, oxaliplatin and carboplatin remains a
challenge for their use as chemotherapies, particularly in breast and colorectal cancer. Here …

Mitophagy, a selective autophagic process, has emerged as a pathway involved in
degrading dysfunctional mitochondria. Herein, new platinum (II)-based chemotherapeutics …

Immunotherapy has emerged as a promising cancer treatment option in recent years. In
immune “hot” tumors, characterized by abundant immune cell infiltration, immunotherapy …

Chlorambucil-platinum (IV) prodrugs exhibit multi-mechanistic chemotherapeutic activity
with promising anticancer potential. The platinum (II) precursors of the prodrugs have been …

The search for better chemotherapeutic drugs to alleviate the deficiencies of existing
platinum (Pt) drugs has picked up the pace in the millennium. There has been a disparate …