The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused the unprecedented COVID-19 pandemic, which has infected over 178 million people …

Objectives Janus kinase inhibitors (JAKi) have been approved for use in various immune-
mediated inflammatory diseases. With five agents licensed, it was timely to summarise the …

Abstract The Janus kinases or JAKs are a family of intracellular tyrosine kinases that play an
essential role in the signaling of numerous cytokines that have been implicated in the …

Protein kinases regulate the majority of signal transduction pathways in cells and have
become important targets for the development of designer drugs. We present a systematic …

Janus kinases (JAK1, JAK2, JAK3, and TYK2) are involved in the signaling of multiple
cytokines important in cellular function. Blockade of the JAK-STAT pathway with a small …

Background: JAK/STAT signal pathway, a requisite part in the signaling process of growth
factors and cytokines, has become attractive targets for numerous immune, inflammatory …

JAK1 plays a significant role in the intracellular signaling by interacting with cytokine
receptors in different types of cells and is linked to the pathogenesis of various cancers and …

In this review, we describe the current knowledge of the biology of the JAKs. The JAK family
comprises the four nonreceptor tyrosine kinases JAK1, JAK2, JAK3, and Tyk2, all key …

Herein we report on the structure-based discovery of a C-2 hydroxyethyl moiety which
provided consistently high levels of selectivity for JAK1 over JAK2 to the …

Herein we report the discovery of the C-2 methyl substituted imidazopyrrolopyridine series
and its optimization to provide potent and orally bioavailable JAK1 inhibitors with selectivity …