It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

Parasites undergo complex life cycles that comprise a wide variety of cellular differentiation
events in different host compartments and transmission across multiple hosts. As parasites …

Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular
parasite that infects warm-blooded vertebrates across the world. In humans, seropositivity …

The enzyme fructose-bisphosphate aldolase occupies a central position in glycolysis and
gluconeogenesis pathways. Beyond its housekeeping role in metabolism, fructose …

Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum
Apicomplexa that infects all warm-blooded animals, including humans. T. gondii can …

Intracellular single-celled parasites belonging to the large phylum Apicomplexa are amongst
the most prevalent and morbidity-causing pathogens worldwide. In this review, we highlight …

The genus Brucella currently comprises twelve species of facultative intracellular bacteria
with variable zoonotic potential. Six of them have been considered as classical, causing …

A number of medically important microbial pathogens target and proliferate within
macrophages and other phagocytic cells in their mammalian hosts. While the majority of …

Obligate intracellular pathogens have coevolved with their host, leading to clever strategies
to access nutrients, to combat the host's immune response, and to establish a safe niche for …

The nature of energy metabolism in apicomplexan parasites has been closely investigated
in the recent years. Studies in Plasmodium spp. and Toxoplasma gondii in particular have …