Prothrombin complex concentrate (PCC) is increasingly being used as a treatment for major
bleeding in patients who are not taking anticoagulants. The aim of this systematic review …

Coagulopathy is a common sequela of traumatic brain injury. Consumptive coagulopathy
and secondary hyperfibrinolysis are associated with hypercoagulability. In addition …

Importance Optimal transfusion strategies in traumatic hemorrhage are unknown. Reports
suggest a beneficial effect of 4-factor prothrombin complex concentrate (4F-PCC) on blood …

Modern four‐factor prothrombin complex concentrate was designed originally for rapid
targeted replacement of the coagulation factors II, VII, IX and X. Dosing strategies for the …

METHODS Two-year (2015–2016) analysis of the American College of Surgeons-Trauma
Quality Improvement Program database. All adult (age≥ 18 years) trauma patients who …

Background Optimal management for trauma-induced coagulopathy (TIC) is a clinical
conundrum. In conjunction with the transfusion of fresh-frozen plasma (FFP), additional …

Background Trauma-induced coagulopathy (TIC) is common in trauma patients with major
hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for …

BACKGROUND The optimal time to initiate chemical thromboprophylaxis (CTP) in patients
who have undergone nonoperative management (NOM) of blunt solid organ injuries (SOI) …

Trauma is a leading cause of death worldwide in persons under 44 years of age, and
uncontrolled haemorrhage is the most common preventable cause of death in this patient …

Objectives: To describe the current state of the art regarding management of the critically ill
trauma patient with an emphasis on initial management in the ICU. Data Sources and Study …