[HTML][HTML] Insertions and deletions in protein evolution and engineering
S Savino, T Desmet, J Franceus - Biotechnology Advances, 2022 - Elsevier
Protein evolution or engineering studies are traditionally focused on amino acid
substitutions and the way these contribute to fitness. Meanwhile, the insertion and deletion …
substitutions and the way these contribute to fitness. Meanwhile, the insertion and deletion …
Old trade, new tricks: insights into the spontaneous mutation process from the partnering of classical mutation accumulation experiments with high-throughput …
V Katju, U Bergthorsson - Genome Biology and Evolution, 2019 - academic.oup.com
Mutations spawn genetic variation which, in turn, fuels evolution. Hence, experimental
investigations into the rate and fitness effects of spontaneous mutations are central to the …
investigations into the rate and fitness effects of spontaneous mutations are central to the …
Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
Mutations are the source of genetic variation and the substrate for evolution. Genome-wide
mutation rates appear to be affected by selection and are probably adaptive. Mutation rates …
mutation rates appear to be affected by selection and are probably adaptive. Mutation rates …
Overlooked roles of DNA damage and maternal age in generating human germline mutations
The textbook view that most germline mutations in mammals arise from replication errors is
indirectly supported by the fact that there are both more mutations and more cell divisions in …
indirectly supported by the fact that there are both more mutations and more cell divisions in …
The genome-wide rate and spectrum of spontaneous mutations differ between haploid and diploid yeast
By altering the dynamics of DNA replication and repair, alternative ploidy states may
experience different rates and types of new mutations, leading to divergent evolutionary …
experience different rates and types of new mutations, leading to divergent evolutionary …
Fine-Grained Analysis of Spontaneous Mutation Spectrum and Frequency in Arabidopsis thaliana
Mutations are the ultimate source of all genetic variation. However, few direct estimates of
the contribution of mutation to molecular genetic variation are available. To address this …
the contribution of mutation to molecular genetic variation are available. To address this …
Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen Cryptococcus deneoformans
We recently reported transposon mutagenesis as a significant driver of spontaneous
mutations in the human fungal pathogen Cryptococcus deneoformans during murine …
mutations in the human fungal pathogen Cryptococcus deneoformans during murine …
Evolution of a minimal cell
RZ Moger-Reischer, JI Glass, KS Wise, L Sun… - Nature, 2023 - nature.com
Possessing only essential genes, a minimal cell can reveal mechanisms and processes that
are critical for the persistence and stability of life,. Here we report on how an engineered …
are critical for the persistence and stability of life,. Here we report on how an engineered …
Mutational biases influence parallel adaptation
A Stoltzfus, DM McCandlish - Molecular biology and evolution, 2017 - academic.oup.com
While mutational biases strongly influence neutral molecular evolution, the role of mutational
biases in shaping the course of adaptation is less clear. Here we consider the frequency of …
biases in shaping the course of adaptation is less clear. Here we consider the frequency of …
Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic
Genomes of tens of thousands of SARS-CoV2 isolates have been sequenced across the
world and the total number of changes (predominantly single base substitutions) in these …
world and the total number of changes (predominantly single base substitutions) in these …