Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …

Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …

The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …

Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …

A delicate equilibrium of WNT agonists and antagonists in the intestinal stem cell (ISC) niche
is critical to maintaining the ISC compartment, as it accommodates the rapid renewal of the …

Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …

Optimization of CRISPR/Cas9-mediated genome engineering has resulted in base editors
that hold promise for mutation repair and disease modeling. Here, we demonstrate the …

The morphology and functionality of the epithelial lining differ along the intestinal tract, but
tissue renewal at all sites is driven by stem cells at the base of crypts,–. Whether stem cell …

Tumors are complex cellular and acellular environments within which cancer clones are
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …