HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …

This review examines the enormous progress that has been made in the past decade in
understanding the origin of HIV, HIV genetic variability, and the impact of global HIV diversity …

AZD1222 (ChAdOx1 nCoV-19), a replication-deficient simian adenovirus–vectored vaccine,
has demonstrated safety, efficacy, and immunogenicity against coronavirus disease 2019 in …

Introduction The development of an effective vaccine to protect against HIV is a longstanding
global health need complicated by challenges inherent to HIV biology and to the execution …

The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …

The global diversity of HIV-1 represents a critical challenge facing HIV-1 vaccine
development. HIV-1 mosaic antigens are bioinformatically optimized immunogens designed …

A number of noteworthy technology advances in DNA vaccines research and development
over the past few years have led to the resurgence of this field as a viable vaccine modality …

Deep sequencing technologies have the potential to transform the study of highly variable
viral pathogens by providing a rapid and cost-effective approach to sensitively characterize …

Breast cancer (BC) is known to be a highly heterogeneous disease that is clinically
subdivided into four primary molecular subtypes, each having distinct morphology and …

Background Bioinformatically designed mosaic antigens increase the breadth of HIV
vaccine-elicited immunity. This study compared the safety, tolerability, and immunogenicity …