Myopia occurs in more than 50% of the population in many industrialized countries and is
expected to increase; complications associated with axial elongation from myopia are the …

Myopia is of diverse aetiology. A small proportion of myopia is clearly familial, generally
early in onset and of high level, with defined chromosomal localisations and in some cases …

Refractive errors (myopia, hyperopia, and astigmatism) are complex heterogeneous
disorders of the human eye and are ideal for genetic investigation. Moderate to severe …

The identification of myopia susceptibility genes will not only provide insight into the
molecular basis of this significant eye disorder, but will also identify pathways involved in …

Myopia is the most common vision disorder and the leading cause of visual impairment
worldwide. However, gene variants identified to date explain less than 10% of the variance …

Refractive error (ametropia) is present when parallel rays of light entering the
nonaccommodating eye do not focus on the retina. The visual effect is a blurred image …

Purpose: To investigate mutations in 234 genes associated with retinal dystrophies in a
cohort of 298 probands with early-onset high myopia using whole exome sequencing …

purpose. This study was conducted to investigate the genetic component of three Chinese
pedigrees originating from Hong Kong with autosomal dominant high myopia. methods. A …

Purpose A previous study has reported evidence of a strong linkage, but no association,
between paired box gene 6 (PAX6) and myopia. We attempted to replicate these findings …

purpose. To determine the heritability of refractive error and the familial aggregation of
myopia in an older population. methods. Seven hundred fifty-nine siblings (mean age, 73.4 …