Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …

Evolving studies with several different targeted therapeutic agents are demonstrating that
patients with genomic alterations of the target, including amplification, translocation and …

Loss of function of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN)
tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN …

The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated
in many types of cancer. Mechanisms for pathway activation include loss of tumor …

Activation of transcription factor NF-κB is frequently encountered in tumor cells and
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …

The Akt family of serine/threonine protein kinases are key regulators of multiple aspects of
cell behaviour, including proliferation, survival, metabolism, and tumorigenesis. Growth …

Double-strand breaks (DSBs) arise endogenously during normal cellular processes and
exogenously by genotoxic agents such as ionizing radiation (IR). DSBs are one of the most …

Abstract The phosphatidylinositol-3-kinase/Akt and the mammalian target of rapamycin
(PI3K/Akt/mTOR) pathway is one of the most frequently activated signaling pathways in …

A large number of novel therapeutics is currently undergoing clinical evaluation for the
treatment of prostate cancer, and small molecule signal transduction inhibitors are a …

Abstract The phosphoinositide 3-kinase-AKT-mammalian target of rapamycin (PI3K-AKT-
mTOR) pathway is a frequently hyperactivated pathway in cancer and is important for tumor …