Ferroptosis is an iron-dependent cell death form with the characteristic of the excessive
accumulation of lipid peroxidation. In recent ten years, a host of researches suggested that …

Mitochondrial damage is implicated as a major contributing factor for a number of
noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and …

Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key
roles in oxidative metabolism. Mitochondria, as the major site of oxidative reactions, must …

Ferroptosis is an iron-dependent programmed necrosis characterized by glutathione (GSH)
depletion and lipid peroxidation (LPO). Armed with both the pro-and antiferroptosis …

Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects
against redox stress by providing reducing equivalents to antioxidants such as glutathione …

Abstract Parkinson's disease (PD), a common neurodegenerative disease, is typically
associated with the loss of dopaminergic neuron in the substantia nigra pars compacta …

Despite intensive research on peroxisome biochemistry, the role of glutathione in
peroxisomal redox homeostasis has remained a matter of speculation for many years, and …

Metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease
(NAFLD), are rising in both incidence and prevalence and remain a major global health and …

Purpose Photoreceptor degeneration occurs in various retinal diseases including age-
related macular degeneration (AMD), Retinitis pigmentosa (RP), and diabetic retinopathy …