Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the
mucosal surfaces of the host nasopharynx and upper airway. Through a combination of …

Secondary bacterial infections enhance the disease burden of influenza infections
substantially. Streptococcus pneumoniae (the pneumococcus) plays a major role in the …

Streptococcus pneumoniae (pneumococcus) is a leading human respiratory pathogen that
causes a variety of serious mucosal and invasive diseases. D39 is an historically important …

Two main patterns of gene expression of Streptococcus pneumoniae were observed during
infection in the host by quantitative real time RT‐PCR; one was characteristic of bacteria in …

Streptococcus pneumoniae remains a major cause of bacteremia, pneumonia, and otitis
media despite vaccines and effective antibiotics. The neuraminidase of S. pneumoniae …

Current global efforts are focused on exploring alternative pneumococcal vaccine strategies,
aimed at addressing the shortcomings of existing formulations, without compromising …

The correlation between carbohydrate availability, pneumococcal biofilm formation,
nasopharyngeal colonization, and invasion of the host has been investigated. Of a series of …

The thiol-containing tripeptide glutathione is an important cellular constituent of many
eukaryotic and prokaryotic cells. In addition to its disulfide reductase activity, glutathione is …

During infection, Streptococcus pneumoniae exists mainly in sessile biofilms rather than in
planktonic form, except during sepsis. The capacity to form biofilms is believed to be …

Background: Streptococcus pneumoniae is an important human pathogen that can cause
severe invasive pneumococcal diseases (IPDs). The aim of this multicenter study was to …