Preeclampsia, which manifests itself as hypertension, proteinuria, and edema in pregnancy,
requires the presence of trophoblast tissue but not a fetus. It is characterized by abnormal …

Leptin plays an important role in the control of food intake, energy expenditure, metabolism,
and body weight. This hormone also has a key function in the regulation of glucose …

Nitric oxide (NO) is a major paracrine mediator and important regulatory agent in various
female reproductive processes, such as ovulation, implantation, pregnancy maintenance …

Objective: We hypothesized that the endothelial-derived relaxing factor nitric oxide may
contribute to low resting vascular tone and may attenuate vasoconstrictor action in the …

Nitric oxide is thought to be the endogenous endothelium-derived relaxing factor. We
investigated the effects of compounds that either generate nitric oxide intracellularly or …

An increase in blood flow on both sides of the placenta throughout gestation is necessary to
maintain optimal placental and fetal growth. Inadequate blood flow to the placenta is …

This review aims to provide a comprehensive summary of the mechanisms involved in the
physiological adaptation of the vasculature to pregnancy. Profound changes occur both …

Key points A correlation was found between in vivo umbilical artery Doppler velocimetry and
resistance to fetal‐side flow in the human ex vivo dually perfused placenta, highlighting that …

Preeclampsia is associated with increased thromboxane and decreased prostacyclin
production by the placenta. Low-dose aspirin can selectively inhibit thromboxane production …

Fetal growth restriction resulting from reduced placental blood perfusion is a major cause of
neonatal morbidity and mortality. Aside from intense surveillance and early delivery, there is …