Neurodegenerative diseases are debilitating disorders that feature progressive and
selective loss of function or structure of anatomically or physiologically associated neuronal …

Stress-related disorders, such as depression and anxiety, present marked deficits in
behavioral and cognitive functions related to reward. These are highly prevalent disabling …

Reactive oxygen species (ROS) have been shown to play a role in the pathophysiology of
depression. Taking into account that experimental chronic unpredictable stress (CUS) …

Depression is a major mental disease that is ranked as the fourth leading cause of disability.
In order to avoid unwanted adverse reactions, as well as improve efficacy, current …

In this review, we summarize the involvement of ascorbic acid in neurodegenerative
diseases by presenting available evidence on the behavioral and biochemical effects of this …

Olfactory bulbectomy (OB) is an animal model of depression that can mimic symptoms that
are characteristic of depressive patients, such as behavioral, neurochemical and …

Vitamin C (ascorbic acid) is a well-known antioxidant that is involved in anxiety, stress,
depression, fatigue and mood state in humans. Studies have suggested that oxidative stress …

Studies have demonstrated an association between stressful conditions and the onset of
clinical depression. Considering the antidepressant-like properties of ascorbic acid in both …

Background It has been suggested that dysregulation of γ-aminobutyric acid (GABA)-
mediated neurotransmission is involved in the etiology of major depressive disorder and in …

Some studies have demonstrated that ascorbic acid, similarly to ketamine, exhibits
antidepressant-like effects mediated, at least in part, by modulation of the glutamatergic …