Mitochondria, the main provider of energy in eukaryotic cells, contains more than 1000
different proteins and is closely related to the development of cells. However, damaged …

The measurement and application of residual dipolar couplings (RDCs) in solution NMR
studies of biological macromolecules has become well established over the past quarter of a …

A survey, primarily based on work in the authors' laboratory during the last 10 years, is
provided of recent developments in NMR studies of exchange processes involving protein …

The interaction between proteins is a fundamental event for cellular life that is generally
mediated by specialized protein domains or modules. PDZ domains are the largest class of …

DegP is an oligomeric protein with dual protease and chaperone activity that regulates
protein homeostasis and virulence factor trafficking in the periplasm of gram-negative …

The human high-temperature requirement A2 (HtrA2) mitochondrial protease is critical for
cellular proteostasis, with mutations in this enzyme closely associated with the onset of …

The human high-temperature requirement A2 (HtrA2) protein is a trimeric protease that
cleaves misfolded proteins to protect cells from stresses caused by toxic, proteinaceous …

Molecular chaperones are the guardians of the proteome inside the cell. Chaperones
recognize and bind unfolded or misfolded substrates, thereby preventing further …

The periplasmic protein DegP, which is implicated in virulence factor transport leading to
pathogenicity, is a bi-functional protease and chaperone that helps to maintain protein …

The mitochondrial serine protease HtrA2 is a human homolog of the Escherichia coli Deg-
proteins exhibiting chaperone and proteolytic roles. HtrA2 is involved in both apoptotic …